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High spatial resolution scintillator dosimetry of synchrotron microbeams

Microbeam radiation therapy is a novel pre-clinical external beam therapy that uses high-brilliance synchrotron X-rays to deliver the necessary high dose rates. The unique conditions of high dose rate and high spatial fractionation demand a new class of detector to experimentally measure important b...

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Autores principales: Archer, James, Li, Enbang, Davis, Jeremy, Cameron, Matthew, Rosenfeld, Anatoly, Lerch, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499773/
https://www.ncbi.nlm.nih.gov/pubmed/31053762
http://dx.doi.org/10.1038/s41598-019-43349-6
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author Archer, James
Li, Enbang
Davis, Jeremy
Cameron, Matthew
Rosenfeld, Anatoly
Lerch, Michael
author_facet Archer, James
Li, Enbang
Davis, Jeremy
Cameron, Matthew
Rosenfeld, Anatoly
Lerch, Michael
author_sort Archer, James
collection PubMed
description Microbeam radiation therapy is a novel pre-clinical external beam therapy that uses high-brilliance synchrotron X-rays to deliver the necessary high dose rates. The unique conditions of high dose rate and high spatial fractionation demand a new class of detector to experimentally measure important beam quality parameters. Here we demonstrate the highest spatial resolution plastic scintillator fibre-optic dosimeter found in the literature to date and tested it on the Imaging and Medical Beam-Line at the Australian Synchrotron in a X-ray beam where the irradiation dose rate was 4435 Gy/s. With a one-dimensional spatial resolution of 10 μm the detector is able to resolve the individual microbeams (53.7 ± 0.4 μm wide), and measure the peak-to-valley dose ratio to be 55 ± 17. We also investigate the role of radioluminescence in the optical fibre used to transport the scintillation photons, and conclude that it creates a significant contribution to the total light detected.
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spelling pubmed-64997732019-05-17 High spatial resolution scintillator dosimetry of synchrotron microbeams Archer, James Li, Enbang Davis, Jeremy Cameron, Matthew Rosenfeld, Anatoly Lerch, Michael Sci Rep Article Microbeam radiation therapy is a novel pre-clinical external beam therapy that uses high-brilliance synchrotron X-rays to deliver the necessary high dose rates. The unique conditions of high dose rate and high spatial fractionation demand a new class of detector to experimentally measure important beam quality parameters. Here we demonstrate the highest spatial resolution plastic scintillator fibre-optic dosimeter found in the literature to date and tested it on the Imaging and Medical Beam-Line at the Australian Synchrotron in a X-ray beam where the irradiation dose rate was 4435 Gy/s. With a one-dimensional spatial resolution of 10 μm the detector is able to resolve the individual microbeams (53.7 ± 0.4 μm wide), and measure the peak-to-valley dose ratio to be 55 ± 17. We also investigate the role of radioluminescence in the optical fibre used to transport the scintillation photons, and conclude that it creates a significant contribution to the total light detected. Nature Publishing Group UK 2019-05-03 /pmc/articles/PMC6499773/ /pubmed/31053762 http://dx.doi.org/10.1038/s41598-019-43349-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Archer, James
Li, Enbang
Davis, Jeremy
Cameron, Matthew
Rosenfeld, Anatoly
Lerch, Michael
High spatial resolution scintillator dosimetry of synchrotron microbeams
title High spatial resolution scintillator dosimetry of synchrotron microbeams
title_full High spatial resolution scintillator dosimetry of synchrotron microbeams
title_fullStr High spatial resolution scintillator dosimetry of synchrotron microbeams
title_full_unstemmed High spatial resolution scintillator dosimetry of synchrotron microbeams
title_short High spatial resolution scintillator dosimetry of synchrotron microbeams
title_sort high spatial resolution scintillator dosimetry of synchrotron microbeams
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499773/
https://www.ncbi.nlm.nih.gov/pubmed/31053762
http://dx.doi.org/10.1038/s41598-019-43349-6
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