Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of glycolysis and oxidative phosphorylation (OXPHOS), in comparison to naïve T-cell...

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Detalles Bibliográficos
Autores principales: Jones, Nicholas, Vincent, Emma E., Cronin, James G., Panetti, Silvia, Chambers, Megan, Holm, Sean R., Owens, Sian E., Francis, Nigel J., Finlay, David K., Thornton, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499791/
https://www.ncbi.nlm.nih.gov/pubmed/31053703
http://dx.doi.org/10.1038/s41467-019-10023-4

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