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Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression

The aim of this study is to determine whether structural MRI measures are associated with clinical impairment and progression to a Lewy body disease in patients with idiopathic REM sleep behavior disorder (iRBD). Twenty-seven patients with iRBD in addition to patients with de novo PD and healthy con...

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Autores principales: Pereira, Joana B., Weintraub, Daniel, Chahine, Lana, Aarsland, Dag, Hansson, Oskar, Westman, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499806/
https://www.ncbi.nlm.nih.gov/pubmed/31069252
http://dx.doi.org/10.1038/s41531-019-0079-3
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author Pereira, Joana B.
Weintraub, Daniel
Chahine, Lana
Aarsland, Dag
Hansson, Oskar
Westman, Eric
author_facet Pereira, Joana B.
Weintraub, Daniel
Chahine, Lana
Aarsland, Dag
Hansson, Oskar
Westman, Eric
author_sort Pereira, Joana B.
collection PubMed
description The aim of this study is to determine whether structural MRI measures are associated with clinical impairment and progression to a Lewy body disease in patients with idiopathic REM sleep behavior disorder (iRBD). Twenty-seven patients with iRBD in addition to patients with de novo PD and healthy controls were included from the Parkinson’s Progression Markers Initiative. Patients with iRBD were followed for up to 3 years. Clinical and MRI measures were compared across groups and the association between clinical features and structural MRI was assessed in iRBD patients. Cox regression analyses were applied to identify risk factors for progressing to a Lewy body disease in iRBD. Our results showed that, at baseline, iRBD patients showed parietal and occipital cortical thinning, compared to controls. They also showed worse motor and non-motor abilities, some of which correlated with motor, frontal or temporal cortical thinning. At follow-up, six (22%) iRBD patients were diagnosed with a Lewy body disorder. These patients showed cortical thinning in frontal, occipital and parietal areas compared to iRBD non-converters. Cortical thinning was a significant predictor for future development of a Lewy body disorder (HR: 0.784; 95% CI: 0.640–0.960; p = 0.02). We conclude that cortical thinning is associated with worse motor and non-motor abilities, and predicts conversion to a Lewy body disorder in iRBD, suggesting it could be used to select candidates for clinical trials to delay the onset of neurodegenerative disease.
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spelling pubmed-64998062019-05-08 Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression Pereira, Joana B. Weintraub, Daniel Chahine, Lana Aarsland, Dag Hansson, Oskar Westman, Eric NPJ Parkinsons Dis Article The aim of this study is to determine whether structural MRI measures are associated with clinical impairment and progression to a Lewy body disease in patients with idiopathic REM sleep behavior disorder (iRBD). Twenty-seven patients with iRBD in addition to patients with de novo PD and healthy controls were included from the Parkinson’s Progression Markers Initiative. Patients with iRBD were followed for up to 3 years. Clinical and MRI measures were compared across groups and the association between clinical features and structural MRI was assessed in iRBD patients. Cox regression analyses were applied to identify risk factors for progressing to a Lewy body disease in iRBD. Our results showed that, at baseline, iRBD patients showed parietal and occipital cortical thinning, compared to controls. They also showed worse motor and non-motor abilities, some of which correlated with motor, frontal or temporal cortical thinning. At follow-up, six (22%) iRBD patients were diagnosed with a Lewy body disorder. These patients showed cortical thinning in frontal, occipital and parietal areas compared to iRBD non-converters. Cortical thinning was a significant predictor for future development of a Lewy body disorder (HR: 0.784; 95% CI: 0.640–0.960; p = 0.02). We conclude that cortical thinning is associated with worse motor and non-motor abilities, and predicts conversion to a Lewy body disorder in iRBD, suggesting it could be used to select candidates for clinical trials to delay the onset of neurodegenerative disease. Nature Publishing Group UK 2019-05-03 /pmc/articles/PMC6499806/ /pubmed/31069252 http://dx.doi.org/10.1038/s41531-019-0079-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pereira, Joana B.
Weintraub, Daniel
Chahine, Lana
Aarsland, Dag
Hansson, Oskar
Westman, Eric
Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression
title Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression
title_full Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression
title_fullStr Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression
title_full_unstemmed Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression
title_short Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression
title_sort cortical thinning in patients with rem sleep behavior disorder is associated with clinical progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499806/
https://www.ncbi.nlm.nih.gov/pubmed/31069252
http://dx.doi.org/10.1038/s41531-019-0079-3
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