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Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry
OBJECTIVE: To assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors. METHODS: Women diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on soc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499868/ https://www.ncbi.nlm.nih.gov/pubmed/30328539 http://dx.doi.org/10.1007/s00520-018-4510-9 |
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author | Rietveld, Mark J. A. Husson, Olga Vos, M. C. (Caroline) van de Poll-Franse, Lonneke V. Ottevanger, P. B. (Nelleke) Ezendam, Nicole P. M. |
author_facet | Rietveld, Mark J. A. Husson, Olga Vos, M. C. (Caroline) van de Poll-Franse, Lonneke V. Ottevanger, P. B. (Nelleke) Ezendam, Nicole P. M. |
author_sort | Rietveld, Mark J. A. |
collection | PubMed |
description | OBJECTIVE: To assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors. METHODS: Women diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on socio-demographic characteristics, HRQoL (EORTC-QLQ-C30), ovarian cancer-specific symptoms including GI (EORTC-QLQ OV28), and psychological distress (HADS). Data collection took place in 2012. RESULTS: Of 348 women diagnosed with ovarian cancer, 191 (55%) responded. Of all participants, 69% were eligible for analysis (n = 131). In 25% of all women, high level GI symptoms occurred (n = 33). In 23% of all women, recurrence of OC occurred (n = 30). Regression analysis showed that presence of high levels of GI symptoms during survivorship was associated with lower functioning on all HRQoL domains (except for emotional functioning), more symptoms, and higher levels of distress. QoL was negatively affected in those who had few and high levels of GI symptoms. QoL of those with recurrent disease was worse than those without recurrent disease. CONCLUSION: A substantial proportion of OC survivors experience GI symptoms, regardless of the recurrence of disease. Health care professionals should be aware of GI symptoms during survivorship in order to refer their patients for supportive care interventions to reduce symptoms or help survivors to cope. Further research should examine the cause of GI symptoms during OC survivorship among those with non-recurrent disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-018-4510-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6499868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-64998682019-05-20 Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry Rietveld, Mark J. A. Husson, Olga Vos, M. C. (Caroline) van de Poll-Franse, Lonneke V. Ottevanger, P. B. (Nelleke) Ezendam, Nicole P. M. Support Care Cancer Original Article OBJECTIVE: To assess the association between gastro-intestinal (GI) symptoms and health-related quality of life (HRQoL) in ovarian cancer (OC) survivors. METHODS: Women diagnosed with OC between 2000 and 2010 as registered in the Netherlands cancer registry (n = 348), received a questionnaire on socio-demographic characteristics, HRQoL (EORTC-QLQ-C30), ovarian cancer-specific symptoms including GI (EORTC-QLQ OV28), and psychological distress (HADS). Data collection took place in 2012. RESULTS: Of 348 women diagnosed with ovarian cancer, 191 (55%) responded. Of all participants, 69% were eligible for analysis (n = 131). In 25% of all women, high level GI symptoms occurred (n = 33). In 23% of all women, recurrence of OC occurred (n = 30). Regression analysis showed that presence of high levels of GI symptoms during survivorship was associated with lower functioning on all HRQoL domains (except for emotional functioning), more symptoms, and higher levels of distress. QoL was negatively affected in those who had few and high levels of GI symptoms. QoL of those with recurrent disease was worse than those without recurrent disease. CONCLUSION: A substantial proportion of OC survivors experience GI symptoms, regardless of the recurrence of disease. Health care professionals should be aware of GI symptoms during survivorship in order to refer their patients for supportive care interventions to reduce symptoms or help survivors to cope. Further research should examine the cause of GI symptoms during OC survivorship among those with non-recurrent disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-018-4510-9) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-10-17 2019 /pmc/articles/PMC6499868/ /pubmed/30328539 http://dx.doi.org/10.1007/s00520-018-4510-9 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Rietveld, Mark J. A. Husson, Olga Vos, M. C. (Caroline) van de Poll-Franse, Lonneke V. Ottevanger, P. B. (Nelleke) Ezendam, Nicole P. M. Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry |
title | Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry |
title_full | Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry |
title_fullStr | Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry |
title_full_unstemmed | Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry |
title_short | Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry |
title_sort | presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the profiles registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499868/ https://www.ncbi.nlm.nih.gov/pubmed/30328539 http://dx.doi.org/10.1007/s00520-018-4510-9 |
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