DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

BACKGROUND: Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and color...

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Detalles Bibliográficos
Autores principales: Weigel, Christoph, Chaisaingmongkol, Jittiporn, Assenov, Yassen, Kuhmann, Christine, Winkler, Volker, Santi, Irene, Bogatyrova, Olga, Kaucher, Simone, Bermejo, Justo L., Leung, Suet Y., Chan, Tsun L., Lasitschka, Felix, Bohrer, Manfred H., Marx, Alexander, Haußen, Roland Heyny-von, Herold-Mende, Christel, Dyckhoff, Gerhard, Boukamp, Petra, Delank, Klaus W., Hörmann, Karl, Lippert, Burkhard M., Baier, Gerald, Dietz, Andreas, Oakes, Christopher C., Plass, Christoph, Becher, Heiko, Schmezer, Peter, Ramroth, Heribert, Popanda, Odilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499986/
https://www.ncbi.nlm.nih.gov/pubmed/31053176
http://dx.doi.org/10.1186/s13148-019-0666-5

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