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Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

BACKGROUND: Celastrol, a triterpene compound derived from the traditional Chinese medicine Tripterygium wilfordii, has been reported to possess potential antitumor activity towards various malignancies. However, the effect of celastrol on glioma cells and the underlying molecular mechanisms remain e...

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Detalles Bibliográficos
Autores principales:	Liu, Xihong, Zhao, Peiyuan, Wang, Xiujuan, Wang, Lei, Zhu, Yingjun, Song, Yadi, Gao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500040/ https://www.ncbi.nlm.nih.gov/pubmed/31053160 http://dx.doi.org/10.1186/s13046-019-1173-4

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