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Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protective variant in native Ethiopian goats

BACKGROUND: Polymorphisms of the prion protein gene may influence scrapie susceptibility in small ruminants through modified protein conformation. At least 47 amino acid substitutions and 19 silent polymorphisms have been described in goat PRNP reported from several countries. The objective of this...

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Detalles Bibliográficos
Autores principales:	Vitale, Maria, Migliore, Sergio, Tilahun, Berhanu, Abdurahaman, Mukarim, Tolone, Marco, Sammarco, Ignazio, Di Marco Lo Presti, Vincenzo, Gebremedhin, Endrias Zewdu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500044/ https://www.ncbi.nlm.nih.gov/pubmed/31053138 http://dx.doi.org/10.1186/s12917-019-1870-4

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