Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design

BACKGROUND: Falcipains are major cysteine proteases of Plasmodium falciparum involved in haemoglobin degradation and remain attractive anti-malarial drug targets. Several inhibitors against these proteases have been identified, yet none of them has been approved for malaria treatment. Other Plasmodi...

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Detalles Bibliográficos
Autores principales: Musyoka, Thommas Mutemi, Njuguna, Joyce Njoki, Tastan Bishop, Özlem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500056/
https://www.ncbi.nlm.nih.gov/pubmed/31053072
http://dx.doi.org/10.1186/s12936-019-2790-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500056/
https://www.ncbi.nlm.nih.gov/pubmed/31053072
http://dx.doi.org/10.1186/s12936-019-2790-2

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