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Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review

INTRODUCTION: First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research questi...

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Autores principales: Ashton, Melanie M, Berk, Michael, Ng, Chee H, Hopwood, Malcolm, Kavanagh, Bianca, Williams, Lana J, Sarris, Jerome, Dean, Olivia M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500254/
https://www.ncbi.nlm.nih.gov/pubmed/30948585
http://dx.doi.org/10.1136/bmjopen-2018-025640
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author Ashton, Melanie M
Berk, Michael
Ng, Chee H
Hopwood, Malcolm
Kavanagh, Bianca
Williams, Lana J
Sarris, Jerome
Dean, Olivia M
author_facet Ashton, Melanie M
Berk, Michael
Ng, Chee H
Hopwood, Malcolm
Kavanagh, Bianca
Williams, Lana J
Sarris, Jerome
Dean, Olivia M
author_sort Ashton, Melanie M
collection PubMed
description INTRODUCTION: First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms? METHODS AND ANALYSIS: Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. ETHICS AND DISSEMINATION: This review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences. PROSPERO REGISTRATION NUMBER: CRD42019100745.
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spelling pubmed-65002542019-05-21 Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review Ashton, Melanie M Berk, Michael Ng, Chee H Hopwood, Malcolm Kavanagh, Bianca Williams, Lana J Sarris, Jerome Dean, Olivia M BMJ Open Mental Health INTRODUCTION: First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms? METHODS AND ANALYSIS: Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. ETHICS AND DISSEMINATION: This review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences. PROSPERO REGISTRATION NUMBER: CRD42019100745. BMJ Publishing Group 2019-04-04 /pmc/articles/PMC6500254/ /pubmed/30948585 http://dx.doi.org/10.1136/bmjopen-2018-025640 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Mental Health
Ashton, Melanie M
Berk, Michael
Ng, Chee H
Hopwood, Malcolm
Kavanagh, Bianca
Williams, Lana J
Sarris, Jerome
Dean, Olivia M
Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
title Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
title_full Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
title_fullStr Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
title_full_unstemmed Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
title_short Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
title_sort nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
topic Mental Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500254/
https://www.ncbi.nlm.nih.gov/pubmed/30948585
http://dx.doi.org/10.1136/bmjopen-2018-025640
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