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Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation
In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbid...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500391/ https://www.ncbi.nlm.nih.gov/pubmed/31061639 http://dx.doi.org/10.5114/wo.2019.83815 |
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author | Yaman, Yöntem Baysoy, Gökhan Keleşoğlu, Emre Özdilli, Kürşat Çakır, Aslı Genç, Dildar Bahar Elli, Murat Anak, Sema |
author_facet | Yaman, Yöntem Baysoy, Gökhan Keleşoğlu, Emre Özdilli, Kürşat Çakır, Aslı Genç, Dildar Bahar Elli, Murat Anak, Sema |
author_sort | Yaman, Yöntem |
collection | PubMed |
description | In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT. |
format | Online Article Text |
id | pubmed-6500391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-65003912019-05-06 Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation Yaman, Yöntem Baysoy, Gökhan Keleşoğlu, Emre Özdilli, Kürşat Çakır, Aslı Genç, Dildar Bahar Elli, Murat Anak, Sema Contemp Oncol (Pozn) Case Report In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT. Termedia Publishing House 2019-03-25 2019 /pmc/articles/PMC6500391/ /pubmed/31061639 http://dx.doi.org/10.5114/wo.2019.83815 Text en Copyright: © 2019 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Case Report Yaman, Yöntem Baysoy, Gökhan Keleşoğlu, Emre Özdilli, Kürşat Çakır, Aslı Genç, Dildar Bahar Elli, Murat Anak, Sema Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
title | Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
title_full | Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
title_fullStr | Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
title_full_unstemmed | Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
title_short | Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
title_sort | graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500391/ https://www.ncbi.nlm.nih.gov/pubmed/31061639 http://dx.doi.org/10.5114/wo.2019.83815 |
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