Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi

Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10...

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Autores principales: Bennett, Aisleen, Pollock, Louisa, Jere, Khuzwayo C, Pitzer, Virginia E, Lopman, Benjamin, Parashar, Umesh, Everett, Dean, Heyderman, Robert S, Bar-Zeev, Naor, Cunliffe, Nigel A, Iturriza-Gomara, Miren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500552/
https://www.ncbi.nlm.nih.gov/pubmed/30689911
http://dx.doi.org/10.1093/infdis/jiz002
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author Bennett, Aisleen
Pollock, Louisa
Jere, Khuzwayo C
Pitzer, Virginia E
Lopman, Benjamin
Parashar, Umesh
Everett, Dean
Heyderman, Robert S
Bar-Zeev, Naor
Cunliffe, Nigel A
Iturriza-Gomara, Miren
author_facet Bennett, Aisleen
Pollock, Louisa
Jere, Khuzwayo C
Pitzer, Virginia E
Lopman, Benjamin
Parashar, Umesh
Everett, Dean
Heyderman, Robert S
Bar-Zeev, Naor
Cunliffe, Nigel A
Iturriza-Gomara, Miren
author_sort Bennett, Aisleen
collection PubMed
description Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8–10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.
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spelling pubmed-65005522019-05-08 Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi Bennett, Aisleen Pollock, Louisa Jere, Khuzwayo C Pitzer, Virginia E Lopman, Benjamin Parashar, Umesh Everett, Dean Heyderman, Robert S Bar-Zeev, Naor Cunliffe, Nigel A Iturriza-Gomara, Miren J Infect Dis Major Articles and Brief Reports Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8–10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi. Oxford University Press 2019-06-01 2019-01-24 /pmc/articles/PMC6500552/ /pubmed/30689911 http://dx.doi.org/10.1093/infdis/jiz002 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Bennett, Aisleen
Pollock, Louisa
Jere, Khuzwayo C
Pitzer, Virginia E
Lopman, Benjamin
Parashar, Umesh
Everett, Dean
Heyderman, Robert S
Bar-Zeev, Naor
Cunliffe, Nigel A
Iturriza-Gomara, Miren
Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
title Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
title_full Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
title_fullStr Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
title_full_unstemmed Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
title_short Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
title_sort infrequent transmission of monovalent human rotavirus vaccine virus to household contacts of vaccinated infants in malawi
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500552/
https://www.ncbi.nlm.nih.gov/pubmed/30689911
http://dx.doi.org/10.1093/infdis/jiz002
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