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Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?

Epidemiological data indicate that subjects affected by obesity have an increased risk of developing mood disorders. The relationship between obesity and mood disorders is bidirectional. We assessed whether a Hericium erinaceus treatment improved depression, anxiety, sleep, and binge eating disorder...

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Autores principales: Vigna, Luisella, Morelli, Federica, Agnelli, Gianna M., Napolitano, Filomena, Ratto, Daniela, Occhinegro, Alessandra, Di Iorio, Carmine, Savino, Elena, Girometta, Carolina, Brandalise, Federico, Rossi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500611/
https://www.ncbi.nlm.nih.gov/pubmed/31118969
http://dx.doi.org/10.1155/2019/7861297
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author Vigna, Luisella
Morelli, Federica
Agnelli, Gianna M.
Napolitano, Filomena
Ratto, Daniela
Occhinegro, Alessandra
Di Iorio, Carmine
Savino, Elena
Girometta, Carolina
Brandalise, Federico
Rossi, Paola
author_facet Vigna, Luisella
Morelli, Federica
Agnelli, Gianna M.
Napolitano, Filomena
Ratto, Daniela
Occhinegro, Alessandra
Di Iorio, Carmine
Savino, Elena
Girometta, Carolina
Brandalise, Federico
Rossi, Paola
author_sort Vigna, Luisella
collection PubMed
description Epidemiological data indicate that subjects affected by obesity have an increased risk of developing mood disorders. The relationship between obesity and mood disorders is bidirectional. We assessed whether a Hericium erinaceus treatment improved depression, anxiety, sleep, and binge eating disorders after 8 weeks of supplementation in subjects affected by overweight or obesity under a low calorie diet regimen. Looking for a possible clinical biomarker, we assessed the serum balance between brain-derived neurotrophic factor (BDNF) and its precursor pro-BDNF before and after H. erinaceus supplementation. Seventy-seven volunteers affected by overweight or obesity were recruited at the offices of the Department of Preventive Medicine, Luigi Devoto Clinic of Work, Obesity Centre, at the IRCCS Foundation Policlinico Hospital of Milan (Italy). Patients were recruited only if they had a mood and/or sleep disorder and/or were binge eating as evaluated through self-assessment questionnaires. We used two different enzyme-linked immunosorbent assays kits to discriminate circulating levels of pro-BDNF and BDNF. Eight weeks of oral H. erinaceus supplementation decreased depression, anxiety, and sleep disorders. H. erinaceus supplementation improved mood disorders of a depressive-anxious nature and the quality of the nocturnal rest. H. erinaceus increased circulating pro-BDNF levels without any significant change in BDNF circulating levels.
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spelling pubmed-65006112019-05-22 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Vigna, Luisella Morelli, Federica Agnelli, Gianna M. Napolitano, Filomena Ratto, Daniela Occhinegro, Alessandra Di Iorio, Carmine Savino, Elena Girometta, Carolina Brandalise, Federico Rossi, Paola Evid Based Complement Alternat Med Research Article Epidemiological data indicate that subjects affected by obesity have an increased risk of developing mood disorders. The relationship between obesity and mood disorders is bidirectional. We assessed whether a Hericium erinaceus treatment improved depression, anxiety, sleep, and binge eating disorders after 8 weeks of supplementation in subjects affected by overweight or obesity under a low calorie diet regimen. Looking for a possible clinical biomarker, we assessed the serum balance between brain-derived neurotrophic factor (BDNF) and its precursor pro-BDNF before and after H. erinaceus supplementation. Seventy-seven volunteers affected by overweight or obesity were recruited at the offices of the Department of Preventive Medicine, Luigi Devoto Clinic of Work, Obesity Centre, at the IRCCS Foundation Policlinico Hospital of Milan (Italy). Patients were recruited only if they had a mood and/or sleep disorder and/or were binge eating as evaluated through self-assessment questionnaires. We used two different enzyme-linked immunosorbent assays kits to discriminate circulating levels of pro-BDNF and BDNF. Eight weeks of oral H. erinaceus supplementation decreased depression, anxiety, and sleep disorders. H. erinaceus supplementation improved mood disorders of a depressive-anxious nature and the quality of the nocturnal rest. H. erinaceus increased circulating pro-BDNF levels without any significant change in BDNF circulating levels. Hindawi 2019-04-18 /pmc/articles/PMC6500611/ /pubmed/31118969 http://dx.doi.org/10.1155/2019/7861297 Text en Copyright © 2019 Luisella Vigna et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vigna, Luisella
Morelli, Federica
Agnelli, Gianna M.
Napolitano, Filomena
Ratto, Daniela
Occhinegro, Alessandra
Di Iorio, Carmine
Savino, Elena
Girometta, Carolina
Brandalise, Federico
Rossi, Paola
Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
title Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
title_full Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
title_fullStr Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
title_full_unstemmed Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
title_short Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
title_sort hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity: could circulating pro-bdnf and bdnf be potential biomarkers?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500611/
https://www.ncbi.nlm.nih.gov/pubmed/31118969
http://dx.doi.org/10.1155/2019/7861297
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