Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives

Drug-induced liver injury (DILI) is a major concern in clinical studies as well as in postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough investigation of mechanisms of DILI and searching for protective medications. This article reviews the current status an...

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Detalles Bibliográficos
Autores principales: Pan, Yingying, Cao, Mingzhu, You, Danming, Qin, Genggeng, Liu, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500714/
https://www.ncbi.nlm.nih.gov/pubmed/31119149
http://dx.doi.org/10.1155/2019/1283824
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author Pan, Yingying
Cao, Mingzhu
You, Danming
Qin, Genggeng
Liu, Zhi
author_facet Pan, Yingying
Cao, Mingzhu
You, Danming
Qin, Genggeng
Liu, Zhi
author_sort Pan, Yingying
collection PubMed
description Drug-induced liver injury (DILI) is a major concern in clinical studies as well as in postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough investigation of mechanisms of DILI and searching for protective medications. This article reviews the current status and future perspective on establishment of DILI models based on different hepatotoxic drugs, as well as the underlying mechanisms of liver function damage induced by specific medicine. Therefore, information from this article can help researchers make a suitable selection of animal models for further study.
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spelling pubmed-65007142019-05-22 Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives Pan, Yingying Cao, Mingzhu You, Danming Qin, Genggeng Liu, Zhi Biomed Res Int Review Article Drug-induced liver injury (DILI) is a major concern in clinical studies as well as in postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough investigation of mechanisms of DILI and searching for protective medications. This article reviews the current status and future perspective on establishment of DILI models based on different hepatotoxic drugs, as well as the underlying mechanisms of liver function damage induced by specific medicine. Therefore, information from this article can help researchers make a suitable selection of animal models for further study. Hindawi 2019-04-15 /pmc/articles/PMC6500714/ /pubmed/31119149 http://dx.doi.org/10.1155/2019/1283824 Text en Copyright © 2019 Yingying Pan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pan, Yingying
Cao, Mingzhu
You, Danming
Qin, Genggeng
Liu, Zhi
Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives
title Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives
title_full Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives
title_fullStr Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives
title_full_unstemmed Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives
title_short Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives
title_sort research progress on the animal models of drug-induced liver injury: current status and further perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500714/
https://www.ncbi.nlm.nih.gov/pubmed/31119149
http://dx.doi.org/10.1155/2019/1283824
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