Cargando…

Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog

An 8-yr-old French Bulldog was presented with a non-ambulatory tetraparesis. Magnetic resonance showed an intradurally located mass at the level of the right second cervical nerve root. The mass was surgically removed and the dog was ambulatory within 4 d. A 10-mo post-surgical imaging follow-up rev...

Descripción completa

Detalles Bibliográficos
Autores principales: Poli, Federica, Calistri, Maurizio, Mandara, Maria Teresa, Baroni, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of Veterinary Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500854/
https://www.ncbi.nlm.nih.gov/pubmed/31086766
http://dx.doi.org/10.4314/ovj.v9i1.9
_version_ 1783416022576922624
author Poli, Federica
Calistri, Maurizio
Mandara, Maria Teresa
Baroni, Massimo
author_facet Poli, Federica
Calistri, Maurizio
Mandara, Maria Teresa
Baroni, Massimo
author_sort Poli, Federica
collection PubMed
description An 8-yr-old French Bulldog was presented with a non-ambulatory tetraparesis. Magnetic resonance showed an intradurally located mass at the level of the right second cervical nerve root. The mass was surgically removed and the dog was ambulatory within 4 d. A 10-mo post-surgical imaging follow-up revealed a recurrence of the primary mass and another intradural/intramedullary mass at the level of the first thoracic vertebral body. Overall histological features were suggestive of malignant peripheral nerve sheath tumor (MPNST) for both masses. Immunohistochemistry was found weak but diffusely positive for S-100 and neurono-specific enolase for both masses. A diagnosis of primary MPNST for the cervical mass and of metastasis for the thoracic mass was made, possibly disseminated via the subarachnoidal space. To our knowledge, the central nervous system metastasis of MPNSTs has not previously been reported in dogs. The clinician should be aware that these tumors, albeit rarely, can metastasize to the central nervous system.
format Online
Article
Text
id pubmed-6500854
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Faculty of Veterinary Medicine
record_format MEDLINE/PubMed
spelling pubmed-65008542019-05-13 Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog Poli, Federica Calistri, Maurizio Mandara, Maria Teresa Baroni, Massimo Open Vet J Case Report An 8-yr-old French Bulldog was presented with a non-ambulatory tetraparesis. Magnetic resonance showed an intradurally located mass at the level of the right second cervical nerve root. The mass was surgically removed and the dog was ambulatory within 4 d. A 10-mo post-surgical imaging follow-up revealed a recurrence of the primary mass and another intradural/intramedullary mass at the level of the first thoracic vertebral body. Overall histological features were suggestive of malignant peripheral nerve sheath tumor (MPNST) for both masses. Immunohistochemistry was found weak but diffusely positive for S-100 and neurono-specific enolase for both masses. A diagnosis of primary MPNST for the cervical mass and of metastasis for the thoracic mass was made, possibly disseminated via the subarachnoidal space. To our knowledge, the central nervous system metastasis of MPNSTs has not previously been reported in dogs. The clinician should be aware that these tumors, albeit rarely, can metastasize to the central nervous system. Faculty of Veterinary Medicine 2019 2019-03-04 /pmc/articles/PMC6500854/ /pubmed/31086766 http://dx.doi.org/10.4314/ovj.v9i1.9 Text en http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Poli, Federica
Calistri, Maurizio
Mandara, Maria Teresa
Baroni, Massimo
Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
title Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
title_full Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
title_fullStr Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
title_full_unstemmed Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
title_short Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
title_sort central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500854/
https://www.ncbi.nlm.nih.gov/pubmed/31086766
http://dx.doi.org/10.4314/ovj.v9i1.9
work_keys_str_mv AT polifederica centralnervoussystemmetastasisofanintraduralmalignantperipheralnervesheathtumorinadog
AT calistrimaurizio centralnervoussystemmetastasisofanintraduralmalignantperipheralnervesheathtumorinadog
AT mandaramariateresa centralnervoussystemmetastasisofanintraduralmalignantperipheralnervesheathtumorinadog
AT baronimassimo centralnervoussystemmetastasisofanintraduralmalignantperipheralnervesheathtumorinadog