Cargando…

Successful treatment with nivolumab for SMARCA4‐deficient non‐small cell lung carcinoma with a high tumor mutation burden: A case report

SMARCA4 is a subunit of the switch/sucrose non‐fermentable (SWI/SNF) chromatin‐remodeling complex. An effective treatment for SMARCA4‐deficient non‐small cell lung carcinoma (NSCLC) has not yet been established. Correlations between a response to immune checkpoint inhibitors and the SWI/SNF complex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naito, Tomoyuki, Umemura, Shigeki, Nakamura, Hiroshi, Zenke, Yoshitaka, Udagawa, Hibiki, Kirita, Keisuke, Matsumoto, Shingo, Yoh, Kiyotaka, Niho, Seiji, Motoi, Noriko, Aokage, Keijyu, Tsuboi, Masahiro, Ishii, Genichiro, Goto, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons Australia, Ltd 2019
Materias:	Case Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501032/ https://www.ncbi.nlm.nih.gov/pubmed/30972962 http://dx.doi.org/10.1111/1759-7714.13070

Ejemplares similares

Salvage chemoradiotherapy with cisplatin and vinorelbine for postoperative locoregional recurrence of non-small cell lung cancer
por: Hisakane, Kakeru, et al.
Publicado: (2017)

Impressive response to nivolumab of non‐small‐cell lung cancer containing sarcomatoid components
por: Ota, Takahiro, et al.
Publicado: (2019)

Feasibility and utility of transbronchial cryobiopsy in precision medicine for lung cancer: Prospective single‐arm study
por: Udagawa, Hibiki, et al.
Publicado: (2020)

CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors
por: Ishibashi, Masayuki, et al.
Publicado: (2017)

Comparison of the efficiency of endobronchial ultrasound-guided transbronchial needle aspiration using a 22G needle versus 25G needle for the diagnosis of lymph node metastasis in patients with lung cancer: a prospective randomized, crossover study
por: Sakai, Tetsuya, et al.
Publicado: (2021)

Impact of prophylactic cranial irradiation on pattern of brain metastases as a first recurrence site for limited-disease small-cell lung cancer
por: Nakamura, Masaki, et al.
Publicado: (2018)

Impact of concomitant medication on clinical outcomes in patients with advanced non‐small cell lung cancer treated with immune checkpoint inhibitors: A retrospective study
por: Miura, Kaho, et al.
Publicado: (2021)

Identification of Biological Properties of Intralymphatic Tumor Related to the Development of Lymph Node Metastasis in Lung Adenocarcinoma
por: Kirita, Keisuke, et al.
Publicado: (2013)

Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma
por: Ikemura, Shinnosuke, et al.
Publicado: (2017)

Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report
por: Sakai, Takashi, et al.
Publicado: (2019)

Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth
por: Takahashi, Akiko, et al.
Publicado: (2015)

Prognostic impact and gene expression analysis of peri‐tumoral alveolar macrophage in resected lung adenocarcinoma
por: Kagawa, Yosuke, et al.
Publicado: (2023)

Therapeutic Priority of the PI3K/AKT/mTOR Pathway in Small Cell Lung Cancers as Revealed by a Comprehensive Genomic Analysis
por: Umemura, Shigeki, et al.
Publicado: (2014)

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma
por: Matsumura, Yuki, et al.
Publicado: (2015)

Stapling cartridge lavage cytology in limited resection for pulmonary malignant tumors: assessment of cytological status of the surgical margin
por: Miyoshi, Tomohiro, et al.
Publicado: (2019)

A secondary RET mutation in the activation loop conferring resistance to vandetanib
por: Nakaoku, Takashi, et al.
Publicado: (2018)

Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma
por: Matsuwaki, Rie, et al.
Publicado: (2014)

Risk factors associated with fatal pulmonary hemorrhage in locally advanced non-small cell lung cancer treated with chemoradiotherapy
por: Ito, Masami, et al.
Publicado: (2012)

A case of thoracic SMARCA4‐Deficient undifferentiated tumor successfully treated with combination Ipilimumab–Nivolumab
por: Nakano, Yoshio, et al.
Publicado: (2022)

Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
por: Noda‐Narita, Shoko, et al.
Publicado: (2022)

Tumor-identification method for predicting recurrence of early-stage lung adenocarcinoma using digital pathology images by machine learning
por: Hattori, Hideharu, et al.
Publicado: (2022)

Case report: Heterogenous SMARCA4-deficient thoracic non-small cell lung carcinoma with various responses to nivolumab
por: Lin, Yun-Tzu, et al.
Publicado: (2023)

Analysis of SMARCA4 and SMARCA2 Loss in Lung Sarcomatoid Carcinomas
por: Urer, Halide Nur, et al.
Publicado: (2023)

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
por: Makinoshima, Hideki, et al.
Publicado: (2015)

Intracranial complete response for non‐small‐cell lung cancer patient with negative PD‐L1 expression of the lung using nivolumab
por: Kitadai, Rui, et al.
Publicado: (2021)

Impact of Extratumoral Lymphatic Permeation on Postoperative Survival of Non–Small-Cell Lung Cancer Patients
por: Matsumura, Yuki, et al.
Publicado: (2014)

Evaluation of variant frequency in SARS-CoV-2 infection-related genes utilizing lung cancer genomic database
por: Shibata, Yuji, et al.
Publicado: (2021)

Prognostic impact of count of extratumoral lymphatic permeation in lung adenocarcinoma and its relation to the immune microenvironment
por: Niimi, Takahiro, et al.
Publicado: (2022)

Comprehensive biomarker analysis from phase II study of nivolumab in patients with thymic carcinoma
por: Katsuya, Yuki, et al.
Publicado: (2023)

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer
por: Guerrero-Martínez, Jose A., et al.
Publicado: (2018)

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
por: Cantley, Jennifer, et al.
Publicado: (2022)

Observational study to predict the efficacy and optimal duration of nivolumab treatment in patients with previously treated advanced or recurrent non-small cell lung cancer
por: Goto, Yasushi, et al.
Publicado: (2022)

18F‐fluorodeoxyglucose uptake in PET is associated with the tumor microenvironment in metastatic lymph nodes and prognosis in N2 lung adenocarcinoma
por: Nomura, Kotaro, et al.
Publicado: (2022)

Complex Alternative Splicing of the Smarca2 Gene Suggests the Importance of Smarca2-B Variants
por: Yang, Min, et al.
Publicado: (2011)

Notable Response of SMARCA4-Deficient Undifferentiated Uterine Sarcoma to Palliative Radiation Therapy
por: Kurokawa, Mariko, et al.
Publicado: (2021)

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type
por: Jelinic, Petar, et al.
Publicado: (2016)

Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum
por: Konishi, Yasuhito, et al.
Publicado: (2022)

Coordinated epigenetic regulation of Engrailed-1 by the chromatin remodelers Smarca1 and Smarca5 mediates cerebellar morphogenesis
por: Alvarez-Saavedra, Matias, et al.
Publicado: (2013)

Clinical and molecular factors for selection of nivolumab or irinotecan as third-line treatment for advanced gastric cancer
por: Ishii, Takahiro, et al.
Publicado: (2020)

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines
por: Ehrenhöfer-Wölfer, Katharina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_r8r7g4uqfdhuaip2jjqr87dkg3