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Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism

A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone s...

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Detalles Bibliográficos
Autores principales: de Oliveira, Miriane, Rodrigues, Bruna Moretto, Olimpio, Regiane Marques Castro, Graceli, Jones Bernardes, Gonçalves, Bianca Mariani, Costa, Sarah Maria Barneze, da Silva, Tabata Marinda, De Sibio, Maria Teresa, Moretto, Fernanda Cristina Fontes, Mathias, Lucas Solla, Cardoso, Dariane Beatriz Marino, Tilli, Helena Paim, Freitas-Lima, Leandro Ceotto, Nogueira, Celia Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501155/
https://www.ncbi.nlm.nih.gov/pubmed/31178910
http://dx.doi.org/10.1155/2019/7396716
Descripción
Sumario:A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also cause abnormal functions. Thyroid hormone (TH) disruption is defined as an abnormal change in TH production, transport, function, or metabolism, which results in some degree of impairment in body homeostasis. Many EDCs, including organotin compounds (OTCs), are environmental contaminants that are commonly found in antifouling paints used on ships and in several other industrial procedures. OTCs are obesogenic and can disrupt TH metabolism; however, abnormalities in thyroid function resulting from OTC exposure are less well understood. OTCs, one of the most prevalent EDCs that are encountered on a daily basis, modulate the thyroid axis. In most toxicology studies, it has been reported that OTCs might contribute to hypothyroidism.