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Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility
OBJECTIVES: Premature myocardial infarction (PMI) is an uncommon disease, and its incidence varies between 2% and 10%, rising, depending on genetic susceptibility under the influence of lifestyle. The purpose of this study was to investigate the association between SIRT1 single nucleotide polymorphi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501229/ https://www.ncbi.nlm.nih.gov/pubmed/31143479 http://dx.doi.org/10.1155/2019/8921806 |
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author | Yamac, Aylin Hatice Uysal, Omer Ismailoglu, Ziya Ertürk, Mehmet Celikten, Mert Bacaksiz, Ahmet Kilic, Ulkan |
author_facet | Yamac, Aylin Hatice Uysal, Omer Ismailoglu, Ziya Ertürk, Mehmet Celikten, Mert Bacaksiz, Ahmet Kilic, Ulkan |
author_sort | Yamac, Aylin Hatice |
collection | PubMed |
description | OBJECTIVES: Premature myocardial infarction (PMI) is an uncommon disease, and its incidence varies between 2% and 10%, rising, depending on genetic susceptibility under the influence of lifestyle. The purpose of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs), SIRT1, and eNOS (endothelial nitric oxide synthase) protein expressions, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in young patients with premature ST-elevation myocardial infarction (STEMI). METHODS: Genotyping of the three single-nucleotide polymorphisms (rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5) in SIRT1 gene was performed in 108 consecutive patients (87.0% were men with a mean age of 40.74 ± 3.82 years) suffering from ST-elevation myocardial infarction at the age of ≤45 and 91 control subjects. RESULTS: The risk for myocardial infarction was increased by 2.31 times in carriers of CC or CG genotypes. SIRT1 protein levels were enhanced and endothelial nitric oxide synthase levels were diminished in ST-elevation myocardial infarction patients regardless of the underlying gene variant. There was no correlation between SIRT1 expression and the amount of endothelial nitric oxide synthase, total antioxidant status, total oxidant status, and oxidative stress index levels in patients and in the control group either. CONCLUSIONS: SIRT1 single-nucleotide polymorphisms were associated with premature myocardial infarction, which affected the SIRT1 and endothelial nitric oxide synthase protein expression, irrespective of the underlying SIRT1 genotype. |
format | Online Article Text |
id | pubmed-6501229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65012292019-05-29 Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility Yamac, Aylin Hatice Uysal, Omer Ismailoglu, Ziya Ertürk, Mehmet Celikten, Mert Bacaksiz, Ahmet Kilic, Ulkan Cardiol Res Pract Research Article OBJECTIVES: Premature myocardial infarction (PMI) is an uncommon disease, and its incidence varies between 2% and 10%, rising, depending on genetic susceptibility under the influence of lifestyle. The purpose of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs), SIRT1, and eNOS (endothelial nitric oxide synthase) protein expressions, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in young patients with premature ST-elevation myocardial infarction (STEMI). METHODS: Genotyping of the three single-nucleotide polymorphisms (rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5) in SIRT1 gene was performed in 108 consecutive patients (87.0% were men with a mean age of 40.74 ± 3.82 years) suffering from ST-elevation myocardial infarction at the age of ≤45 and 91 control subjects. RESULTS: The risk for myocardial infarction was increased by 2.31 times in carriers of CC or CG genotypes. SIRT1 protein levels were enhanced and endothelial nitric oxide synthase levels were diminished in ST-elevation myocardial infarction patients regardless of the underlying gene variant. There was no correlation between SIRT1 expression and the amount of endothelial nitric oxide synthase, total antioxidant status, total oxidant status, and oxidative stress index levels in patients and in the control group either. CONCLUSIONS: SIRT1 single-nucleotide polymorphisms were associated with premature myocardial infarction, which affected the SIRT1 and endothelial nitric oxide synthase protein expression, irrespective of the underlying SIRT1 genotype. Hindawi 2019-04-15 /pmc/articles/PMC6501229/ /pubmed/31143479 http://dx.doi.org/10.1155/2019/8921806 Text en Copyright © 2019 Aylin Hatice Yamac et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yamac, Aylin Hatice Uysal, Omer Ismailoglu, Ziya Ertürk, Mehmet Celikten, Mert Bacaksiz, Ahmet Kilic, Ulkan Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility |
title | Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility |
title_full | Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility |
title_fullStr | Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility |
title_full_unstemmed | Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility |
title_short | Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility |
title_sort | premature myocardial infarction: genetic variations in sirt1 affect disease susceptibility |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501229/ https://www.ncbi.nlm.nih.gov/pubmed/31143479 http://dx.doi.org/10.1155/2019/8921806 |
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