Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species

Mitofusin-2 (Mfn2) is a key outer mitochondrial membrane protein, which maintains normal mitochondrial dynamics and function. However, its role in cardiac fibroblast activation remains poorly understood. In the present study, a rat model of transverse aortic constriction (TAC) was established to obs...

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Detalles Bibliográficos
Autores principales: Xin, Yanguo, Wu, Wenchao, Qu, Jing, Wang, Xiaojiao, Lei, Song, Yuan, Lixing, Liu, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501253/
https://www.ncbi.nlm.nih.gov/pubmed/31178957
http://dx.doi.org/10.1155/2019/3649808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501253/
https://www.ncbi.nlm.nih.gov/pubmed/31178957
http://dx.doi.org/10.1155/2019/3649808

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