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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
Inflammatory breast cancer (IBC) is the most rare and aggressive subtype of breast cancer characterized by clusters of tumor cells invading lymph vessels, high rates of metastasis, and resistance to systemic chemotherapy. While significant progress has been made in understanding IBC, survival among...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501286/ https://www.ncbi.nlm.nih.gov/pubmed/31060575 http://dx.doi.org/10.1186/s13058-019-1140-1 |
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author | Provance, Olivia K. Lewis-Wambi, Joan |
author_facet | Provance, Olivia K. Lewis-Wambi, Joan |
author_sort | Provance, Olivia K. |
collection | PubMed |
description | Inflammatory breast cancer (IBC) is the most rare and aggressive subtype of breast cancer characterized by clusters of tumor cells invading lymph vessels, high rates of metastasis, and resistance to systemic chemotherapy. While significant progress has been made in understanding IBC, survival among IBC patients is still only one half that among patients with non-IBC. A major limitation to the development of more specific and effective treatments for IBC is a lack of identifiable molecular alterations that are specific to IBC. Emerging evidence suggests that the aggressive nature of IBC is not specific to IBC cells but instead driven by the interplay between autonomous signaling and context-dependent cytokine networks from the surrounding tumor microenvironment. Recently, the type I interferon, specifically the interferon alpha signature, has been identified as a pathway upregulated in IBC but few studies have addressed its role. Activation of the interferon alpha signaling pathway has been shown to contribute to apoptosis and cellular senescence but is also attributed to increased migration and drug resistance depending on the interferon-stimulated genes transcribed. The mechanisms promoting the increase in interferon alpha expression and the role interferon alpha plays in IBC remain speculative. Current hypotheses suggest that immune and stromal cells in the local tumor microenvironment contribute to the interferon alpha signaling cascade within the tumor cell and that this activation may further alter the immune and stromal cells within the microenvironment. This review serves as an overview of the role of interferon alpha signaling in IBC. Ideally, future experiments should investigate the mechanistic interplay of interferons in IBC to develop more efficacious treatment strategies for IBC patients. |
format | Online Article Text |
id | pubmed-6501286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65012862019-05-10 Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer Provance, Olivia K. Lewis-Wambi, Joan Breast Cancer Res Review Inflammatory breast cancer (IBC) is the most rare and aggressive subtype of breast cancer characterized by clusters of tumor cells invading lymph vessels, high rates of metastasis, and resistance to systemic chemotherapy. While significant progress has been made in understanding IBC, survival among IBC patients is still only one half that among patients with non-IBC. A major limitation to the development of more specific and effective treatments for IBC is a lack of identifiable molecular alterations that are specific to IBC. Emerging evidence suggests that the aggressive nature of IBC is not specific to IBC cells but instead driven by the interplay between autonomous signaling and context-dependent cytokine networks from the surrounding tumor microenvironment. Recently, the type I interferon, specifically the interferon alpha signature, has been identified as a pathway upregulated in IBC but few studies have addressed its role. Activation of the interferon alpha signaling pathway has been shown to contribute to apoptosis and cellular senescence but is also attributed to increased migration and drug resistance depending on the interferon-stimulated genes transcribed. The mechanisms promoting the increase in interferon alpha expression and the role interferon alpha plays in IBC remain speculative. Current hypotheses suggest that immune and stromal cells in the local tumor microenvironment contribute to the interferon alpha signaling cascade within the tumor cell and that this activation may further alter the immune and stromal cells within the microenvironment. This review serves as an overview of the role of interferon alpha signaling in IBC. Ideally, future experiments should investigate the mechanistic interplay of interferons in IBC to develop more efficacious treatment strategies for IBC patients. BioMed Central 2019-05-06 2019 /pmc/articles/PMC6501286/ /pubmed/31060575 http://dx.doi.org/10.1186/s13058-019-1140-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Provance, Olivia K. Lewis-Wambi, Joan Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
title | Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
title_full | Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
title_fullStr | Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
title_full_unstemmed | Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
title_short | Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
title_sort | deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501286/ https://www.ncbi.nlm.nih.gov/pubmed/31060575 http://dx.doi.org/10.1186/s13058-019-1140-1 |
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