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Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma

BACKGROUND: Bite wounds are one of the most common traumatic injuries in dogs and depending on their severity, location, etc., urgent care including antibiotic therapy may be necessary. Serious complications can result from these injuries, such as multiple organ dysfunction syndrome (MODS), as well...

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Autores principales: Lee, Ga-Won, Park, Hee-Myung, Kang, Min-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501374/
https://www.ncbi.nlm.nih.gov/pubmed/31060620
http://dx.doi.org/10.1186/s13028-019-0458-0
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author Lee, Ga-Won
Park, Hee-Myung
Kang, Min-Hee
author_facet Lee, Ga-Won
Park, Hee-Myung
Kang, Min-Hee
author_sort Lee, Ga-Won
collection PubMed
description BACKGROUND: Bite wounds are one of the most common traumatic injuries in dogs and depending on their severity, location, etc., urgent care including antibiotic therapy may be necessary. Serious complications can result from these injuries, such as multiple organ dysfunction syndrome (MODS), as well as a generalized reduction in cerebral perfusion, e.g. during cardiac arrest, shock, or severe hypotension that may cause global brain ischemia (GBI). CASE PRESENTATION: A 5-year-old spayed female Maltese dog was presented with generalized seizures, ataxia, and obtunded mentation. The dog was injured by severe bite wounds that penetrated its abdomen and had received blood transfusions, antibiotic therapy (including metronidazole and cefazoline) and underwent emergency surgery 4 days before its visit. Based on a clinical examination, intracranial hypoxic damage with elevated intra-cranial pressure and MODS were highly suspected, and GBI was confirmed following magnetic resonance imaging. Increased signal intensity diffusely distributed in the olfactory bulb and frontal, temporal, and parietal grey matter was evident on the T2-weighted and fluid attenuated inversion recovery transverse images, along with corresponding high signal intensity observed on diffusion weighted imaging. During the 10-month follow-up period, the clinical signs gradually improved, but intermittent circling and cognitive dysfunction deficits remained. CONCLUSIONS: GBI should be included among the differential diagnoses in case of any peracute non-progressive neurological dysfunction that occurs with episodes of hypotension or hypoxia. The abnormal signal intensity observed on diffusion weighted imaging was a useful indicator for diagnosing this condition. Long-term medical management with antibiotics and anti-convulsant and anti-oxidant therapies were considered to be helpful in managing the GBI concurrent with MODS in this dog.
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spelling pubmed-65013742019-05-10 Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma Lee, Ga-Won Park, Hee-Myung Kang, Min-Hee Acta Vet Scand Case Report BACKGROUND: Bite wounds are one of the most common traumatic injuries in dogs and depending on their severity, location, etc., urgent care including antibiotic therapy may be necessary. Serious complications can result from these injuries, such as multiple organ dysfunction syndrome (MODS), as well as a generalized reduction in cerebral perfusion, e.g. during cardiac arrest, shock, or severe hypotension that may cause global brain ischemia (GBI). CASE PRESENTATION: A 5-year-old spayed female Maltese dog was presented with generalized seizures, ataxia, and obtunded mentation. The dog was injured by severe bite wounds that penetrated its abdomen and had received blood transfusions, antibiotic therapy (including metronidazole and cefazoline) and underwent emergency surgery 4 days before its visit. Based on a clinical examination, intracranial hypoxic damage with elevated intra-cranial pressure and MODS were highly suspected, and GBI was confirmed following magnetic resonance imaging. Increased signal intensity diffusely distributed in the olfactory bulb and frontal, temporal, and parietal grey matter was evident on the T2-weighted and fluid attenuated inversion recovery transverse images, along with corresponding high signal intensity observed on diffusion weighted imaging. During the 10-month follow-up period, the clinical signs gradually improved, but intermittent circling and cognitive dysfunction deficits remained. CONCLUSIONS: GBI should be included among the differential diagnoses in case of any peracute non-progressive neurological dysfunction that occurs with episodes of hypotension or hypoxia. The abnormal signal intensity observed on diffusion weighted imaging was a useful indicator for diagnosing this condition. Long-term medical management with antibiotics and anti-convulsant and anti-oxidant therapies were considered to be helpful in managing the GBI concurrent with MODS in this dog. BioMed Central 2019-05-06 /pmc/articles/PMC6501374/ /pubmed/31060620 http://dx.doi.org/10.1186/s13028-019-0458-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Lee, Ga-Won
Park, Hee-Myung
Kang, Min-Hee
Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
title Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
title_full Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
title_fullStr Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
title_full_unstemmed Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
title_short Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
title_sort global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501374/
https://www.ncbi.nlm.nih.gov/pubmed/31060620
http://dx.doi.org/10.1186/s13028-019-0458-0
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