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Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway

Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, and tissue remodeling. Renal toxicity of high IS concentrations (250 μM) has been widely explored, particularly in...

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Detalles Bibliográficos
Autores principales:	Milanesi, Samantha, Garibaldi, Silvano, Saio, Michela, Ghigliotti, Giorgio, Picciotto, Daniela, Ameri, Pietro, Garibotto, Giacomo, Barisione, Chiara, Verzola, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501427/ https://www.ncbi.nlm.nih.gov/pubmed/31178953 http://dx.doi.org/10.1155/2019/2050183

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