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Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report

The Hailey–Hailey disease, or familial benign chronic pemphigus, is an autosomal dominant genodermatosis affecting mainly intertriginous areas. It manifests itself in painful blisters, erosions, and cracks and has a chronic course with frequent flares, significantly impacting patients’ quality of li...

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Autores principales: Lapa, Tatiana, Breslavets, Maksym
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501477/
https://www.ncbi.nlm.nih.gov/pubmed/31105943
http://dx.doi.org/10.1177/2050313X19845221
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author Lapa, Tatiana
Breslavets, Maksym
author_facet Lapa, Tatiana
Breslavets, Maksym
author_sort Lapa, Tatiana
collection PubMed
description The Hailey–Hailey disease, or familial benign chronic pemphigus, is an autosomal dominant genodermatosis affecting mainly intertriginous areas. It manifests itself in painful blisters, erosions, and cracks and has a chronic course with frequent flares, significantly impacting patients’ quality of life. Presently, there is no cure, but multiple treatment modalities are available. Most evidence supports treatment with topical steroids and antimicrobials. Treatment of recalcitrant disease has been shown to benefit from the addition of oral antibiotics, Naltrexone, systemic retinoids, botulinum toxin A injections, laser treatment, and surgical excision. We describe a case of refractory Hailey–Hailey disease for which most of the abovementioned options failed, but which demonstrated significant improvement following a combination of oral acitretin and narrowband ultraviolet-B phototherapy. To achieve remission, the patient received 30 sessions three times per week with the increment of 20 mJ/cm(2) per session and oral acitretin 25 mg PO daily.
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spelling pubmed-65014772019-05-17 Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report Lapa, Tatiana Breslavets, Maksym SAGE Open Med Case Rep JCMS Case Report The Hailey–Hailey disease, or familial benign chronic pemphigus, is an autosomal dominant genodermatosis affecting mainly intertriginous areas. It manifests itself in painful blisters, erosions, and cracks and has a chronic course with frequent flares, significantly impacting patients’ quality of life. Presently, there is no cure, but multiple treatment modalities are available. Most evidence supports treatment with topical steroids and antimicrobials. Treatment of recalcitrant disease has been shown to benefit from the addition of oral antibiotics, Naltrexone, systemic retinoids, botulinum toxin A injections, laser treatment, and surgical excision. We describe a case of refractory Hailey–Hailey disease for which most of the abovementioned options failed, but which demonstrated significant improvement following a combination of oral acitretin and narrowband ultraviolet-B phototherapy. To achieve remission, the patient received 30 sessions three times per week with the increment of 20 mJ/cm(2) per session and oral acitretin 25 mg PO daily. SAGE Publications 2019-05-02 /pmc/articles/PMC6501477/ /pubmed/31105943 http://dx.doi.org/10.1177/2050313X19845221 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle JCMS Case Report
Lapa, Tatiana
Breslavets, Maksym
Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report
title Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report
title_full Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report
title_fullStr Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report
title_full_unstemmed Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report
title_short Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report
title_sort treatment of hailey–hailey disease with narrowband phototherapy and acitretin: a case report
topic JCMS Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501477/
https://www.ncbi.nlm.nih.gov/pubmed/31105943
http://dx.doi.org/10.1177/2050313X19845221
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