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Advances in cerebral amyloid angiopathy imaging
Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease. The high recurrent hemorrhage rate in CAA make...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501479/ https://www.ncbi.nlm.nih.gov/pubmed/31105769 http://dx.doi.org/10.1177/1756286419844113 |
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author | Chen, Szu-Ju Tsai, Hsin-Hsi Tsai, Li-Kai Tang, Sung-Chun Lee, Bo-Chin Liu, Hon-Man Yen, Ruoh-Fang Jeng, Jiann-Shing |
author_facet | Chen, Szu-Ju Tsai, Hsin-Hsi Tsai, Li-Kai Tang, Sung-Chun Lee, Bo-Chin Liu, Hon-Man Yen, Ruoh-Fang Jeng, Jiann-Shing |
author_sort | Chen, Szu-Ju |
collection | PubMed |
description | Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease. The high recurrent hemorrhage rate in CAA makes it very important to recognize this disease to avoid potential harmful medication. Imaging studies play an important role in diagnosis and research of CAA. Conventional computed tomography and magnetic resonance imaging (MRI) methods reveal anatomical alterations, and remains as the most reliable tool in identifying CAA according to modified Boston criteria. The vascular injuries of CAA result in both hemorrhagic and ischemic manifestations and related structural changes on MRI, including cerebral microbleeds, cortical superficial siderosis, white matter hyperintensity, MRI-visible perivascular spaces, and cortical microinfarcts. As imaging techniques advance, not only does the resolution of conventional imaging improve, but novel skills in functional and molecular imaging studies also enable in vivo analysis of vessel physiological changes and underlying pathology. These modern tools help in early detection of CAA and may potentially serve as sensitive outcome markers in future clinical trials. In this article, we reviewed past studies of CAA focusing on utilization of various conventional and novel imaging techniques in both research and clinical aspects. |
format | Online Article Text |
id | pubmed-6501479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-65014792019-05-17 Advances in cerebral amyloid angiopathy imaging Chen, Szu-Ju Tsai, Hsin-Hsi Tsai, Li-Kai Tang, Sung-Chun Lee, Bo-Chin Liu, Hon-Man Yen, Ruoh-Fang Jeng, Jiann-Shing Ther Adv Neurol Disord Advances in Neuroimaging Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease. The high recurrent hemorrhage rate in CAA makes it very important to recognize this disease to avoid potential harmful medication. Imaging studies play an important role in diagnosis and research of CAA. Conventional computed tomography and magnetic resonance imaging (MRI) methods reveal anatomical alterations, and remains as the most reliable tool in identifying CAA according to modified Boston criteria. The vascular injuries of CAA result in both hemorrhagic and ischemic manifestations and related structural changes on MRI, including cerebral microbleeds, cortical superficial siderosis, white matter hyperintensity, MRI-visible perivascular spaces, and cortical microinfarcts. As imaging techniques advance, not only does the resolution of conventional imaging improve, but novel skills in functional and molecular imaging studies also enable in vivo analysis of vessel physiological changes and underlying pathology. These modern tools help in early detection of CAA and may potentially serve as sensitive outcome markers in future clinical trials. In this article, we reviewed past studies of CAA focusing on utilization of various conventional and novel imaging techniques in both research and clinical aspects. SAGE Publications 2019-05-03 /pmc/articles/PMC6501479/ /pubmed/31105769 http://dx.doi.org/10.1177/1756286419844113 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Advances in Neuroimaging Chen, Szu-Ju Tsai, Hsin-Hsi Tsai, Li-Kai Tang, Sung-Chun Lee, Bo-Chin Liu, Hon-Man Yen, Ruoh-Fang Jeng, Jiann-Shing Advances in cerebral amyloid angiopathy imaging |
title | Advances in cerebral amyloid angiopathy imaging |
title_full | Advances in cerebral amyloid angiopathy imaging |
title_fullStr | Advances in cerebral amyloid angiopathy imaging |
title_full_unstemmed | Advances in cerebral amyloid angiopathy imaging |
title_short | Advances in cerebral amyloid angiopathy imaging |
title_sort | advances in cerebral amyloid angiopathy imaging |
topic | Advances in Neuroimaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501479/ https://www.ncbi.nlm.nih.gov/pubmed/31105769 http://dx.doi.org/10.1177/1756286419844113 |
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