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Advances in cerebral amyloid angiopathy imaging

Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease. The high recurrent hemorrhage rate in CAA make...

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Autores principales: Chen, Szu-Ju, Tsai, Hsin-Hsi, Tsai, Li-Kai, Tang, Sung-Chun, Lee, Bo-Chin, Liu, Hon-Man, Yen, Ruoh-Fang, Jeng, Jiann-Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501479/
https://www.ncbi.nlm.nih.gov/pubmed/31105769
http://dx.doi.org/10.1177/1756286419844113
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author Chen, Szu-Ju
Tsai, Hsin-Hsi
Tsai, Li-Kai
Tang, Sung-Chun
Lee, Bo-Chin
Liu, Hon-Man
Yen, Ruoh-Fang
Jeng, Jiann-Shing
author_facet Chen, Szu-Ju
Tsai, Hsin-Hsi
Tsai, Li-Kai
Tang, Sung-Chun
Lee, Bo-Chin
Liu, Hon-Man
Yen, Ruoh-Fang
Jeng, Jiann-Shing
author_sort Chen, Szu-Ju
collection PubMed
description Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease. The high recurrent hemorrhage rate in CAA makes it very important to recognize this disease to avoid potential harmful medication. Imaging studies play an important role in diagnosis and research of CAA. Conventional computed tomography and magnetic resonance imaging (MRI) methods reveal anatomical alterations, and remains as the most reliable tool in identifying CAA according to modified Boston criteria. The vascular injuries of CAA result in both hemorrhagic and ischemic manifestations and related structural changes on MRI, including cerebral microbleeds, cortical superficial siderosis, white matter hyperintensity, MRI-visible perivascular spaces, and cortical microinfarcts. As imaging techniques advance, not only does the resolution of conventional imaging improve, but novel skills in functional and molecular imaging studies also enable in vivo analysis of vessel physiological changes and underlying pathology. These modern tools help in early detection of CAA and may potentially serve as sensitive outcome markers in future clinical trials. In this article, we reviewed past studies of CAA focusing on utilization of various conventional and novel imaging techniques in both research and clinical aspects.
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spelling pubmed-65014792019-05-17 Advances in cerebral amyloid angiopathy imaging Chen, Szu-Ju Tsai, Hsin-Hsi Tsai, Li-Kai Tang, Sung-Chun Lee, Bo-Chin Liu, Hon-Man Yen, Ruoh-Fang Jeng, Jiann-Shing Ther Adv Neurol Disord Advances in Neuroimaging Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease. The high recurrent hemorrhage rate in CAA makes it very important to recognize this disease to avoid potential harmful medication. Imaging studies play an important role in diagnosis and research of CAA. Conventional computed tomography and magnetic resonance imaging (MRI) methods reveal anatomical alterations, and remains as the most reliable tool in identifying CAA according to modified Boston criteria. The vascular injuries of CAA result in both hemorrhagic and ischemic manifestations and related structural changes on MRI, including cerebral microbleeds, cortical superficial siderosis, white matter hyperintensity, MRI-visible perivascular spaces, and cortical microinfarcts. As imaging techniques advance, not only does the resolution of conventional imaging improve, but novel skills in functional and molecular imaging studies also enable in vivo analysis of vessel physiological changes and underlying pathology. These modern tools help in early detection of CAA and may potentially serve as sensitive outcome markers in future clinical trials. In this article, we reviewed past studies of CAA focusing on utilization of various conventional and novel imaging techniques in both research and clinical aspects. SAGE Publications 2019-05-03 /pmc/articles/PMC6501479/ /pubmed/31105769 http://dx.doi.org/10.1177/1756286419844113 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Advances in Neuroimaging
Chen, Szu-Ju
Tsai, Hsin-Hsi
Tsai, Li-Kai
Tang, Sung-Chun
Lee, Bo-Chin
Liu, Hon-Man
Yen, Ruoh-Fang
Jeng, Jiann-Shing
Advances in cerebral amyloid angiopathy imaging
title Advances in cerebral amyloid angiopathy imaging
title_full Advances in cerebral amyloid angiopathy imaging
title_fullStr Advances in cerebral amyloid angiopathy imaging
title_full_unstemmed Advances in cerebral amyloid angiopathy imaging
title_short Advances in cerebral amyloid angiopathy imaging
title_sort advances in cerebral amyloid angiopathy imaging
topic Advances in Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501479/
https://www.ncbi.nlm.nih.gov/pubmed/31105769
http://dx.doi.org/10.1177/1756286419844113
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