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Gene drives as a new quality in GMO releases—a comparative technology characterization

Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be released in a parti...

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Autores principales: Frieß, Johannes L., von Gleich, Arnim, Giese, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501761/
https://www.ncbi.nlm.nih.gov/pubmed/31110918
http://dx.doi.org/10.7717/peerj.6793
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author Frieß, Johannes L.
von Gleich, Arnim
Giese, Bernd
author_facet Frieß, Johannes L.
von Gleich, Arnim
Giese, Bernd
author_sort Frieß, Johannes L.
collection PubMed
description Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be released in a particular region. However, now a type of genetic technology arises whose innermost principle lies in exceeding these limits—the transformation or even eradication of wild populations. The invasive character of gene drives demands a thorough analysis of their functionalities, reliability and potential impact. But such investigations are hindered by the fact that an experimental field test would hardly be reversible. Therefore, an appropriate prospective assessment is of utmost importance for an estimation of the risk potential associated with the application of gene drives. This work is meant to support the inevitable characterization of gene drives by a comparative approach of prospective technology assessment with a focus on potential sources of risk. Therein, the hazard and exposure potential as well as uncertainties with regard to the performance of synthetic gene drives are addressed. Moreover, a quantitative analysis of their invasiveness should enable a differentiated evaluation of their power to transform wild populations.
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spelling pubmed-65017612019-05-20 Gene drives as a new quality in GMO releases—a comparative technology characterization Frieß, Johannes L. von Gleich, Arnim Giese, Bernd PeerJ Biotechnology Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be released in a particular region. However, now a type of genetic technology arises whose innermost principle lies in exceeding these limits—the transformation or even eradication of wild populations. The invasive character of gene drives demands a thorough analysis of their functionalities, reliability and potential impact. But such investigations are hindered by the fact that an experimental field test would hardly be reversible. Therefore, an appropriate prospective assessment is of utmost importance for an estimation of the risk potential associated with the application of gene drives. This work is meant to support the inevitable characterization of gene drives by a comparative approach of prospective technology assessment with a focus on potential sources of risk. Therein, the hazard and exposure potential as well as uncertainties with regard to the performance of synthetic gene drives are addressed. Moreover, a quantitative analysis of their invasiveness should enable a differentiated evaluation of their power to transform wild populations. PeerJ Inc. 2019-05-03 /pmc/articles/PMC6501761/ /pubmed/31110918 http://dx.doi.org/10.7717/peerj.6793 Text en ©2019 Frieß et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biotechnology
Frieß, Johannes L.
von Gleich, Arnim
Giese, Bernd
Gene drives as a new quality in GMO releases—a comparative technology characterization
title Gene drives as a new quality in GMO releases—a comparative technology characterization
title_full Gene drives as a new quality in GMO releases—a comparative technology characterization
title_fullStr Gene drives as a new quality in GMO releases—a comparative technology characterization
title_full_unstemmed Gene drives as a new quality in GMO releases—a comparative technology characterization
title_short Gene drives as a new quality in GMO releases—a comparative technology characterization
title_sort gene drives as a new quality in gmo releases—a comparative technology characterization
topic Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501761/
https://www.ncbi.nlm.nih.gov/pubmed/31110918
http://dx.doi.org/10.7717/peerj.6793
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