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Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations

AIM: In this study, we used a series of diallelic genetic marker insertion/deletion polymorphism (indel) to investigate three populations of Yao, Kelao, and Zhuang groups in the Guangxi region of China and to evaluate their efficiency in forensic application. RESULT: No deviations for all 30 loci we...

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Autores principales: Du, Weian, Feng, Chunlei, Yao, Ting, Xiao, Cheng, Huang, Hongyan, Wu, Weibin, Zhu, Linnan, Qiao, Honghua, Liu, Chao, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501771/
https://www.ncbi.nlm.nih.gov/pubmed/31110924
http://dx.doi.org/10.7717/peerj.6861
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author Du, Weian
Feng, Chunlei
Yao, Ting
Xiao, Cheng
Huang, Hongyan
Wu, Weibin
Zhu, Linnan
Qiao, Honghua
Liu, Chao
Chen, Ling
author_facet Du, Weian
Feng, Chunlei
Yao, Ting
Xiao, Cheng
Huang, Hongyan
Wu, Weibin
Zhu, Linnan
Qiao, Honghua
Liu, Chao
Chen, Ling
author_sort Du, Weian
collection PubMed
description AIM: In this study, we used a series of diallelic genetic marker insertion/deletion polymorphism (indel) to investigate three populations of Yao, Kelao, and Zhuang groups in the Guangxi region of China and to evaluate their efficiency in forensic application. RESULT: No deviations for all 30 loci were observed from the Hardy–Weinberg equilibrium after Bonferroni correction (p > 0.05/30 = 0.0017). The allele frequencies of the short allele (DIP-) for the above three populations were in the range of 0.0520–0.9480, 0.0950–0.8780, and 0.0850–0.915, respectively. The observed heterozygosity of the 30 loci for the three populations was in the ranges 0.0802–0.5802, 0.1908–0.6053, and 0.1400–0.5600, respectively. The cumulative power of exclusion and combined discrimination power for Yao, Kelao, and Zhuang groups were (0.9843 and 0.9999999999433), (0.9972 and 0.9999999999184), and (0.9845 and 0.9999999999608), respectively. The DA distance, principal component analysis, and cluster analysis indicated a clear regional distribution. In addition, Zhuang groups had close genetic relationships with the Yao and Kelao populations in the Guangxi region. CONCLUSION: This study indicated that the 30 loci were qualified for personal identification; moreover, they could be used as complementary genetic markers for paternity testing in forensic cases for the studied populations.
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spelling pubmed-65017712019-05-20 Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations Du, Weian Feng, Chunlei Yao, Ting Xiao, Cheng Huang, Hongyan Wu, Weibin Zhu, Linnan Qiao, Honghua Liu, Chao Chen, Ling PeerJ Genetics AIM: In this study, we used a series of diallelic genetic marker insertion/deletion polymorphism (indel) to investigate three populations of Yao, Kelao, and Zhuang groups in the Guangxi region of China and to evaluate their efficiency in forensic application. RESULT: No deviations for all 30 loci were observed from the Hardy–Weinberg equilibrium after Bonferroni correction (p > 0.05/30 = 0.0017). The allele frequencies of the short allele (DIP-) for the above three populations were in the range of 0.0520–0.9480, 0.0950–0.8780, and 0.0850–0.915, respectively. The observed heterozygosity of the 30 loci for the three populations was in the ranges 0.0802–0.5802, 0.1908–0.6053, and 0.1400–0.5600, respectively. The cumulative power of exclusion and combined discrimination power for Yao, Kelao, and Zhuang groups were (0.9843 and 0.9999999999433), (0.9972 and 0.9999999999184), and (0.9845 and 0.9999999999608), respectively. The DA distance, principal component analysis, and cluster analysis indicated a clear regional distribution. In addition, Zhuang groups had close genetic relationships with the Yao and Kelao populations in the Guangxi region. CONCLUSION: This study indicated that the 30 loci were qualified for personal identification; moreover, they could be used as complementary genetic markers for paternity testing in forensic cases for the studied populations. PeerJ Inc. 2019-05-03 /pmc/articles/PMC6501771/ /pubmed/31110924 http://dx.doi.org/10.7717/peerj.6861 Text en © 2019 Du et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Genetics
Du, Weian
Feng, Chunlei
Yao, Ting
Xiao, Cheng
Huang, Hongyan
Wu, Weibin
Zhu, Linnan
Qiao, Honghua
Liu, Chao
Chen, Ling
Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations
title Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations
title_full Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations
title_fullStr Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations
title_full_unstemmed Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations
title_short Genetic variation and forensic efficiency of 30 indels for three ethnic groups in Guangxi: relationships with other populations
title_sort genetic variation and forensic efficiency of 30 indels for three ethnic groups in guangxi: relationships with other populations
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501771/
https://www.ncbi.nlm.nih.gov/pubmed/31110924
http://dx.doi.org/10.7717/peerj.6861
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