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Could decorin be a biomarker of coronary artery disease? A pilot study in human beings

Background and aim: Nowadays there is a strong necessity in identifying patients who may be exposed to the risk for future cardiovascular events like progressive atherosclerotic disease. Biomarkers are valuable tools for this purpose. Coronary artery calcification (CAC) is utilized as an important t...

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Autores principales: Saeed, Nazemi, Atefeh, Rezapour, Seyed, Mohammad Hassan Moallem, Mohammad, Afshar, Sepideh, Elyasi, Hamid, Reza Mashreghi Moghadam, Mahmoud, Dargahi Zaboli, Amir, Hooshang Mohammadpour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502117/
https://www.ncbi.nlm.nih.gov/pubmed/30333460
http://dx.doi.org/10.23750/abm.v89i3.6024
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author Saeed, Nazemi
Atefeh, Rezapour
Seyed, Mohammad Hassan Moallem
Mohammad, Afshar
Sepideh, Elyasi
Hamid, Reza Mashreghi Moghadam
Mahmoud, Dargahi Zaboli
Amir, Hooshang Mohammadpour
author_facet Saeed, Nazemi
Atefeh, Rezapour
Seyed, Mohammad Hassan Moallem
Mohammad, Afshar
Sepideh, Elyasi
Hamid, Reza Mashreghi Moghadam
Mahmoud, Dargahi Zaboli
Amir, Hooshang Mohammadpour
author_sort Saeed, Nazemi
collection PubMed
description Background and aim: Nowadays there is a strong necessity in identifying patients who may be exposed to the risk for future cardiovascular events like progressive atherosclerotic disease. Biomarkers are valuable tools for this purpose. Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk. Decorin (DCN) is a small leucine-rich proteoglycan that induces calcification of arterial smooth muscle cell and localizes to mineral deposition in human atherosclerotic plaque. The main purpose of this clinical study was to find out the correlation between Decorin serum concentration and CAC in human for the first time. Methods:In this study 84 patients with coronary artery disease who fulfilled inclusion and exclusion criteria, entered the study. For all patients a questionnaire consisting demographic data and traditional cardiovascular risk factors were completed. CT-Angiography was carried out to determine coronary artery calcium score and ELISA method was used for measuring DCN serum concentrations. Results:No significant correlation between DCN serum concentration and total CAC score and also CAC of left anterior descending, right coronary artery, left main coronary artery and circumflex was found in the study population (P>0.05). Conclusions:On the basis of our results DCN serum concentration is not a suitable biomarker of coronary artery disease. However, more studies with higher sample size are necessary for its confirmation. (www.actabiomedica.it)
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spelling pubmed-65021172019-05-08 Could decorin be a biomarker of coronary artery disease? A pilot study in human beings Saeed, Nazemi Atefeh, Rezapour Seyed, Mohammad Hassan Moallem Mohammad, Afshar Sepideh, Elyasi Hamid, Reza Mashreghi Moghadam Mahmoud, Dargahi Zaboli Amir, Hooshang Mohammadpour Acta Biomed Original Article Background and aim: Nowadays there is a strong necessity in identifying patients who may be exposed to the risk for future cardiovascular events like progressive atherosclerotic disease. Biomarkers are valuable tools for this purpose. Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk. Decorin (DCN) is a small leucine-rich proteoglycan that induces calcification of arterial smooth muscle cell and localizes to mineral deposition in human atherosclerotic plaque. The main purpose of this clinical study was to find out the correlation between Decorin serum concentration and CAC in human for the first time. Methods:In this study 84 patients with coronary artery disease who fulfilled inclusion and exclusion criteria, entered the study. For all patients a questionnaire consisting demographic data and traditional cardiovascular risk factors were completed. CT-Angiography was carried out to determine coronary artery calcium score and ELISA method was used for measuring DCN serum concentrations. Results:No significant correlation between DCN serum concentration and total CAC score and also CAC of left anterior descending, right coronary artery, left main coronary artery and circumflex was found in the study population (P>0.05). Conclusions:On the basis of our results DCN serum concentration is not a suitable biomarker of coronary artery disease. However, more studies with higher sample size are necessary for its confirmation. (www.actabiomedica.it) Mattioli 1885 2018 /pmc/articles/PMC6502117/ /pubmed/30333460 http://dx.doi.org/10.23750/abm.v89i3.6024 Text en Copyright: © 2018 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article
Saeed, Nazemi
Atefeh, Rezapour
Seyed, Mohammad Hassan Moallem
Mohammad, Afshar
Sepideh, Elyasi
Hamid, Reza Mashreghi Moghadam
Mahmoud, Dargahi Zaboli
Amir, Hooshang Mohammadpour
Could decorin be a biomarker of coronary artery disease? A pilot study in human beings
title Could decorin be a biomarker of coronary artery disease? A pilot study in human beings
title_full Could decorin be a biomarker of coronary artery disease? A pilot study in human beings
title_fullStr Could decorin be a biomarker of coronary artery disease? A pilot study in human beings
title_full_unstemmed Could decorin be a biomarker of coronary artery disease? A pilot study in human beings
title_short Could decorin be a biomarker of coronary artery disease? A pilot study in human beings
title_sort could decorin be a biomarker of coronary artery disease? a pilot study in human beings
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502117/
https://www.ncbi.nlm.nih.gov/pubmed/30333460
http://dx.doi.org/10.23750/abm.v89i3.6024
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