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Drug-induced anaphylaxis in children

Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbid...

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Autores principales: Fabio, Cardinale, Doriana, Amato, Maria, Felicia Mastrototaro, Carlo, Caffarelli, Giuseppe, Crisafulli, Fabrizio, Franceschini, Lucia, Liotti, Silvia, Caimmi, Paolo, Bottau, Francesca, Saretta, Francesca, Mori, Roberto, Bernardini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502178/
https://www.ncbi.nlm.nih.gov/pubmed/30830059
http://dx.doi.org/10.23750/abm.v90i3-S.8172
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author Fabio, Cardinale
Doriana, Amato
Maria, Felicia Mastrototaro
Carlo, Caffarelli
Giuseppe, Crisafulli
Fabrizio, Franceschini
Lucia, Liotti
Silvia, Caimmi
Paolo, Bottau
Francesca, Saretta
Francesca, Mori
Roberto, Bernardini
author_facet Fabio, Cardinale
Doriana, Amato
Maria, Felicia Mastrototaro
Carlo, Caffarelli
Giuseppe, Crisafulli
Fabrizio, Franceschini
Lucia, Liotti
Silvia, Caimmi
Paolo, Bottau
Francesca, Saretta
Francesca, Mori
Roberto, Bernardini
author_sort Fabio, Cardinale
collection PubMed
description Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are the main elicitors in drug-induced anaphylaxis in children. Both immune-mediated (mainly IgE-mediated) and non immune-mediated may be involved. IgG-mediated and complement-mediated mechanisms has been also hypothesized. Correct management relies on a right diagnosis and prompt therapy. A proper work-up is also important to prevent further potentially fatal re-exposures to the same drug or other structurally similar molecules but also unnecessary avoidance of medications not representing the culprit of the episode. (www.actabiomedica.it)
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spelling pubmed-65021782019-05-08 Drug-induced anaphylaxis in children Fabio, Cardinale Doriana, Amato Maria, Felicia Mastrototaro Carlo, Caffarelli Giuseppe, Crisafulli Fabrizio, Franceschini Lucia, Liotti Silvia, Caimmi Paolo, Bottau Francesca, Saretta Francesca, Mori Roberto, Bernardini Acta Biomed Review Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are the main elicitors in drug-induced anaphylaxis in children. Both immune-mediated (mainly IgE-mediated) and non immune-mediated may be involved. IgG-mediated and complement-mediated mechanisms has been also hypothesized. Correct management relies on a right diagnosis and prompt therapy. A proper work-up is also important to prevent further potentially fatal re-exposures to the same drug or other structurally similar molecules but also unnecessary avoidance of medications not representing the culprit of the episode. (www.actabiomedica.it) Mattioli 1885 2019 /pmc/articles/PMC6502178/ /pubmed/30830059 http://dx.doi.org/10.23750/abm.v90i3-S.8172 Text en Copyright: © 2019 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Review
Fabio, Cardinale
Doriana, Amato
Maria, Felicia Mastrototaro
Carlo, Caffarelli
Giuseppe, Crisafulli
Fabrizio, Franceschini
Lucia, Liotti
Silvia, Caimmi
Paolo, Bottau
Francesca, Saretta
Francesca, Mori
Roberto, Bernardini
Drug-induced anaphylaxis in children
title Drug-induced anaphylaxis in children
title_full Drug-induced anaphylaxis in children
title_fullStr Drug-induced anaphylaxis in children
title_full_unstemmed Drug-induced anaphylaxis in children
title_short Drug-induced anaphylaxis in children
title_sort drug-induced anaphylaxis in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502178/
https://www.ncbi.nlm.nih.gov/pubmed/30830059
http://dx.doi.org/10.23750/abm.v90i3-S.8172
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