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The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity
Task-evoked Blood-oxygenation-level-dependent (BOLD-fMRI) signal activation is widely used to interrogate eloquence of brain areas. However, data interpretation can be improved, especially in regions with absent BOLD-fMRI signal activation. Absent BOLD-fMRI signal activation may actually represent f...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502350/ https://www.ncbi.nlm.nih.gov/pubmed/31059517 http://dx.doi.org/10.1371/journal.pone.0215294 |
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author | van Niftrik, Christiaan Hendrik Bas Piccirelli, Marco Muscas, Giovanni Sebök, Martina Fisher, Joseph Arnold Bozinov, Oliver Stippich, Christoph Valavanis, Antonios Regli, Luca Fierstra, Jorn |
author_facet | van Niftrik, Christiaan Hendrik Bas Piccirelli, Marco Muscas, Giovanni Sebök, Martina Fisher, Joseph Arnold Bozinov, Oliver Stippich, Christoph Valavanis, Antonios Regli, Luca Fierstra, Jorn |
author_sort | van Niftrik, Christiaan Hendrik Bas |
collection | PubMed |
description | Task-evoked Blood-oxygenation-level-dependent (BOLD-fMRI) signal activation is widely used to interrogate eloquence of brain areas. However, data interpretation can be improved, especially in regions with absent BOLD-fMRI signal activation. Absent BOLD-fMRI signal activation may actually represent false-negative activation due to impaired cerebrovascular reactivity (BOLD-CVR) of the vascular bed. The relationship between impaired BOLD-CVR and BOLD-fMRI signal activation may be better studied in healthy subjects where neurovascular coupling is known to be intact. Using a model-based prospective end-tidal carbon dioxide (CO(2)) targeting algorithm, we performed two controlled 3 tesla BOLD-CVR studies on 17 healthy subjects: 1: at the subjects’ individual resting end-tidal CO(2) baseline. 2: Around +6.0 mmHg CO(2) above the subjects’ individual resting baseline. Two BOLD-fMRI finger-tapping experiments were performed at similar normo- and hypercapnic levels. Relative BOLD fMRI signal activation and t-values were calculated for BOLD-CVR and BOLD-fMRI data. For each component of the cerebral motor-network (precentral gyrus, postcentral gyrus, supplementary motor area, cerebellum und fronto-operculum), the correlation between BOLD-CVR and BOLD-fMRI signal changes and t-values was investigated. Finally, a voxel-wise quantitative analysis of the impact of BOLD-CVR on BOLD-fMRI was performed. For the motor-network, the linear correlation coefficient between BOLD-CVR and BOLD-fMRI t-values were significant (p<0.01) and in the range 0.33–0.55, similar to the correlations between the CVR and fMRI Δ%signal (p<0.05; range 0.34–0.60). The linear relationship between CVR and fMRI is challenged by our voxel-wise analysis of Δ%signal and t-value change between normo- and hypercapnia. Our main finding is that BOLD fMRI signal activation maps are markedly dampened in the presence of impaired BOLD-CVR and highlights the importance of a complementary BOLD-CVR assessment in addition to a task-evoked BOLD fMRI to identify brain areas at risk for false-negative BOLD-fMRI signal activation. |
format | Online Article Text |
id | pubmed-6502350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-65023502019-05-23 The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity van Niftrik, Christiaan Hendrik Bas Piccirelli, Marco Muscas, Giovanni Sebök, Martina Fisher, Joseph Arnold Bozinov, Oliver Stippich, Christoph Valavanis, Antonios Regli, Luca Fierstra, Jorn PLoS One Research Article Task-evoked Blood-oxygenation-level-dependent (BOLD-fMRI) signal activation is widely used to interrogate eloquence of brain areas. However, data interpretation can be improved, especially in regions with absent BOLD-fMRI signal activation. Absent BOLD-fMRI signal activation may actually represent false-negative activation due to impaired cerebrovascular reactivity (BOLD-CVR) of the vascular bed. The relationship between impaired BOLD-CVR and BOLD-fMRI signal activation may be better studied in healthy subjects where neurovascular coupling is known to be intact. Using a model-based prospective end-tidal carbon dioxide (CO(2)) targeting algorithm, we performed two controlled 3 tesla BOLD-CVR studies on 17 healthy subjects: 1: at the subjects’ individual resting end-tidal CO(2) baseline. 2: Around +6.0 mmHg CO(2) above the subjects’ individual resting baseline. Two BOLD-fMRI finger-tapping experiments were performed at similar normo- and hypercapnic levels. Relative BOLD fMRI signal activation and t-values were calculated for BOLD-CVR and BOLD-fMRI data. For each component of the cerebral motor-network (precentral gyrus, postcentral gyrus, supplementary motor area, cerebellum und fronto-operculum), the correlation between BOLD-CVR and BOLD-fMRI signal changes and t-values was investigated. Finally, a voxel-wise quantitative analysis of the impact of BOLD-CVR on BOLD-fMRI was performed. For the motor-network, the linear correlation coefficient between BOLD-CVR and BOLD-fMRI t-values were significant (p<0.01) and in the range 0.33–0.55, similar to the correlations between the CVR and fMRI Δ%signal (p<0.05; range 0.34–0.60). The linear relationship between CVR and fMRI is challenged by our voxel-wise analysis of Δ%signal and t-value change between normo- and hypercapnia. Our main finding is that BOLD fMRI signal activation maps are markedly dampened in the presence of impaired BOLD-CVR and highlights the importance of a complementary BOLD-CVR assessment in addition to a task-evoked BOLD fMRI to identify brain areas at risk for false-negative BOLD-fMRI signal activation. Public Library of Science 2019-05-06 /pmc/articles/PMC6502350/ /pubmed/31059517 http://dx.doi.org/10.1371/journal.pone.0215294 Text en © 2019 van Niftrik et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article van Niftrik, Christiaan Hendrik Bas Piccirelli, Marco Muscas, Giovanni Sebök, Martina Fisher, Joseph Arnold Bozinov, Oliver Stippich, Christoph Valavanis, Antonios Regli, Luca Fierstra, Jorn The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity |
title | The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity |
title_full | The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity |
title_fullStr | The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity |
title_full_unstemmed | The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity |
title_short | The voxel-wise analysis of false negative fMRI activation in regions of provoked impaired cerebrovascular reactivity |
title_sort | voxel-wise analysis of false negative fmri activation in regions of provoked impaired cerebrovascular reactivity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502350/ https://www.ncbi.nlm.nih.gov/pubmed/31059517 http://dx.doi.org/10.1371/journal.pone.0215294 |
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