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The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania

The intracellular protozoan parasite Leishmania donovani causes human visceral leishmaniasis. Intracellular L. donovani that proliferate inside macrophage phagolysosomes compete with the host for arginine, creating a situation that endangers parasite survival. Parasites have a sensor that upon argin...

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Detalles Bibliográficos
Autores principales: Pawar, Harsh, Puri, Madhu, Fischer Weinberger, Renana, Madhubala, Rentala, Zilberstein, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502434/
https://www.ncbi.nlm.nih.gov/pubmed/31017889
http://dx.doi.org/10.1371/journal.pntd.0007304

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