The Noonan Syndrome-linked Raf1(L613V) mutation drives increased glial number in the mouse cortex and enhanced learning

RASopathies are a family of related syndromes caused by mutations in regulators of the RAS/Extracellular Regulated Kinase 1/2 (ERK1/2) signaling cascade that often result in neurological deficits. RASopathy mutations in upstream regulatory components, such as NF1, PTPN11/SHP2, and RAS have been well...

Descripción completa

Detalles Bibliográficos
Autores principales: Holter, Michael C., Hewitt, Lauren. T., Koebele, Stephanie V., Judd, Jessica M., Xing, Lei, Bimonte-Nelson, Heather A., Conrad, Cheryl D., Araki, Toshiyuki, Neel, Benjamin G., Snider, William D., Newbern, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502435/
https://www.ncbi.nlm.nih.gov/pubmed/31017896
http://dx.doi.org/10.1371/journal.pgen.1008108

Ejemplares similares

Ejemplares similares