Single-molecule kinetics of pore assembly by the membrane attack complex

The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about the rate-limiting steps in this process. Here,...

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Detalles Bibliográficos
Autores principales: Parsons, Edward S., Stanley, George J., Pyne, Alice L. B., Hodel, Adrian W., Nievergelt, Adrian P., Menny, Anaïs, Yon, Alexander R., Rowley, Ashlea, Richter, Ralf P., Fantner, Georg E., Bubeck, Doryen, Hoogenboom, Bart W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502846/
https://www.ncbi.nlm.nih.gov/pubmed/31061395
http://dx.doi.org/10.1038/s41467-019-10058-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502846/
https://www.ncbi.nlm.nih.gov/pubmed/31061395
http://dx.doi.org/10.1038/s41467-019-10058-7

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