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The role of membrane excitability in pancreatic β-cell glucotoxicity

Persistent hyperglycemia is causally associated with pancreatic β-cell dysfunction and loss of pancreatic insulin. Glucose normally enhances β-cell excitability through inhibition of K(ATP) channels, opening of voltage-dependent calcium channels, increased [Ca(2+)](i), which triggers insulin secreti...

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Detalles Bibliográficos
Autores principales:	Shyr, Zeenat A., Wang, Zhiyu, York, Nathaniel W., Nichols, Colin G., Remedi, Maria S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502887/ https://www.ncbi.nlm.nih.gov/pubmed/31061431 http://dx.doi.org/10.1038/s41598-019-43452-8

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