Cargando…
Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a significant contributor to global hepatic disorders. ADIPOQ gene single‐nucleotide polymorphisms have been associated with NAFLD susceptibility, but with inconsistent results across the studies. This study aimed to investigate the association...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503060/ https://www.ncbi.nlm.nih.gov/pubmed/30838812 http://dx.doi.org/10.1002/mgg3.624 |
_version_ | 1783416344856756224 |
---|---|
author | Liu, Mengwei Liu, Shan Shang, Mengke Liu, Xiuping Wang, Yue Li, Qian Mambiya, Michael Yang, Luping Zhang, Qian Zhang, Kaili Nie, Fangfang Zeng, Fanxin Liu, Wanyang |
author_facet | Liu, Mengwei Liu, Shan Shang, Mengke Liu, Xiuping Wang, Yue Li, Qian Mambiya, Michael Yang, Luping Zhang, Qian Zhang, Kaili Nie, Fangfang Zeng, Fanxin Liu, Wanyang |
author_sort | Liu, Mengwei |
collection | PubMed |
description | BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a significant contributor to global hepatic disorders. ADIPOQ gene single‐nucleotide polymorphisms have been associated with NAFLD susceptibility, but with inconsistent results across the studies. This study aimed to investigate the association between ADIPOQ polymorphisms (+276G>T, rs1501299 and −11377C>G, rs266729) and the risk of NAFLD. METHODS: PubMed, Embase, Wanfang, Web of Science, and China National Knowledge Infrastructure databases were used to identify the relevant published literature. Statistical analyses were calculated with STATA 11.0 software and RevMan 5.2. Summary odds ratios (OR) and 95% confidence intervals (CIs) were generated to assess the strength of the associations. RESULTS: Eleven relevant articles with a total of 3,644 participants (1,847 cases/1,797 controls) were included. Our meta‐analysis results revealed that ADIPOQ gene +276G>T polymorphism was not associated with NAFLD under various genetic models (allele model: OR = 0.99, 95% CI [0.69, 1.41]; dominant model: OR = 1.06, 95% CI [0.71, 1.58]; recessive model: OR = 0.83, 95% CI [0.42, 1.65]; homozygous model: OR = 0.86, 95% CI [0.38, 1.95]; heterozygous model: OR = 1.10, 95% CI [0.80, 1.53]; respectively). Moreover, no statistical significant association was found between +276G>T and NAFLD risk in the subgroups. ADIPOQ gene −11377C>G polymorphism significantly increased the risk of NAFLD (allele model: OR = 1.49, 95% CI [1.28, 1.75]; dominant model: OR = 1.64, 95% CI [1.35, 1.99]; recessive model: OR = 1.77, 95% CI [1.16, 2.70]; homozygous model: OR = 2.13, 95% CI [1.38, 3.28]; heterozygous model: OR = 1.58, 95% CI [1.29, 1.93]; respectively). CONCLUSION: ADIPOQ gene −11377C>G may be a risk factor for NAFLD, while there was no association between ADIPOQ gene +276G>T polymorphism and the risk of NAFLD. Further studies are needed to detect the relationship between these ADIPOQ polymorphisms and NAFLD. |
format | Online Article Text |
id | pubmed-6503060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65030602019-05-10 Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis Liu, Mengwei Liu, Shan Shang, Mengke Liu, Xiuping Wang, Yue Li, Qian Mambiya, Michael Yang, Luping Zhang, Qian Zhang, Kaili Nie, Fangfang Zeng, Fanxin Liu, Wanyang Mol Genet Genomic Med Original Articles BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a significant contributor to global hepatic disorders. ADIPOQ gene single‐nucleotide polymorphisms have been associated with NAFLD susceptibility, but with inconsistent results across the studies. This study aimed to investigate the association between ADIPOQ polymorphisms (+276G>T, rs1501299 and −11377C>G, rs266729) and the risk of NAFLD. METHODS: PubMed, Embase, Wanfang, Web of Science, and China National Knowledge Infrastructure databases were used to identify the relevant published literature. Statistical analyses were calculated with STATA 11.0 software and RevMan 5.2. Summary odds ratios (OR) and 95% confidence intervals (CIs) were generated to assess the strength of the associations. RESULTS: Eleven relevant articles with a total of 3,644 participants (1,847 cases/1,797 controls) were included. Our meta‐analysis results revealed that ADIPOQ gene +276G>T polymorphism was not associated with NAFLD under various genetic models (allele model: OR = 0.99, 95% CI [0.69, 1.41]; dominant model: OR = 1.06, 95% CI [0.71, 1.58]; recessive model: OR = 0.83, 95% CI [0.42, 1.65]; homozygous model: OR = 0.86, 95% CI [0.38, 1.95]; heterozygous model: OR = 1.10, 95% CI [0.80, 1.53]; respectively). Moreover, no statistical significant association was found between +276G>T and NAFLD risk in the subgroups. ADIPOQ gene −11377C>G polymorphism significantly increased the risk of NAFLD (allele model: OR = 1.49, 95% CI [1.28, 1.75]; dominant model: OR = 1.64, 95% CI [1.35, 1.99]; recessive model: OR = 1.77, 95% CI [1.16, 2.70]; homozygous model: OR = 2.13, 95% CI [1.38, 3.28]; heterozygous model: OR = 1.58, 95% CI [1.29, 1.93]; respectively). CONCLUSION: ADIPOQ gene −11377C>G may be a risk factor for NAFLD, while there was no association between ADIPOQ gene +276G>T polymorphism and the risk of NAFLD. Further studies are needed to detect the relationship between these ADIPOQ polymorphisms and NAFLD. John Wiley and Sons Inc. 2019-03-05 /pmc/articles/PMC6503060/ /pubmed/30838812 http://dx.doi.org/10.1002/mgg3.624 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Liu, Mengwei Liu, Shan Shang, Mengke Liu, Xiuping Wang, Yue Li, Qian Mambiya, Michael Yang, Luping Zhang, Qian Zhang, Kaili Nie, Fangfang Zeng, Fanxin Liu, Wanyang Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis |
title | Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis |
title_full | Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis |
title_fullStr | Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis |
title_full_unstemmed | Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis |
title_short | Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non‐alcoholic fatty liver disease: An updated meta‐analysis |
title_sort | association between adipoq g276t and c11377g polymorphisms and the risk of non‐alcoholic fatty liver disease: an updated meta‐analysis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503060/ https://www.ncbi.nlm.nih.gov/pubmed/30838812 http://dx.doi.org/10.1002/mgg3.624 |
work_keys_str_mv | AT liumengwei associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT liushan associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT shangmengke associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT liuxiuping associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT wangyue associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT liqian associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT mambiyamichael associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT yangluping associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT zhangqian associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT zhangkaili associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT niefangfang associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT zengfanxin associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis AT liuwanyang associationbetweenadipoqg276tandc11377gpolymorphismsandtheriskofnonalcoholicfattyliverdiseaseanupdatedmetaanalysis |