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Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors
The CRISPR-Cas9 system is used for genome editing in mammalian cells by introducing double-strand breaks (DSBs) which are predominantly repaired via non-homologous end joining (NHEJ) or to lesser extent by homology-directed repair (HDR). To enhance HDR for improving the introduction of precise genet...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503098/ https://www.ncbi.nlm.nih.gov/pubmed/31114605 http://dx.doi.org/10.3389/fgene.2019.00365 |