Cargando…

Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe X-linked neurodevelopmental encephalopathy caused by mutations in the CDKL5 gene and characterized by early-onset epilepsy and intellectual and motor impairments. No cure is currently available for CDD patients, as limited...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Elisa, Roncacé, Vincenzo, Trazzi, Stefania, Fuchs, Claudia, Medici, Giorgio, Gennaccaro, Laura, Loi, Manuela, Galvani, Giuseppe, Ye, Keqiang, Rimondini, Roberto, Aicardi, Giorgio, Ciani, Elisabetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503158/ https://www.ncbi.nlm.nih.gov/pubmed/31114483 http://dx.doi.org/10.3389/fncel.2019.00169

Ejemplares similares

Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
por: Galvani, Giuseppe, et al.
Publicado: (2021)

Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder
por: Tassinari, Marianna, et al.
Publicado: (2022)

Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder
por: Loi, Manuela, et al.
Publicado: (2021)

Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder
por: Fuchs, Claudia, et al.
Publicado: (2018)

Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder
por: Medici, Giorgio, et al.
Publicado: (2022)

Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
por: Mottolese, Nicola, et al.
Publicado: (2023)

Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death
por: Gennaccaro, Laura, et al.
Publicado: (2021)

Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
por: Loi, Manuela, et al.
Publicado: (2023)

Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling
por: Vignoli, Beatrice, et al.
Publicado: (2022)

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders
por: Ademuwagun, Ibitayo Abigail, et al.
Publicado: (2023)

Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder
por: Fuchs, Claudia, et al.
Publicado: (2022)

Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
por: Pankiewicz, Piotr, et al.
Publicado: (2021)

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells
por: Valli, Emanuele, et al.
Publicado: (2012)

Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice
por: Zhou, Si-Bo, et al.
Publicado: (2023)

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin
por: Xiong, Jing, et al.
Publicado: (2022)

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling
por: Fuchs, Claudia, et al.
Publicado: (2014)

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
por: Liu, Chaoyang, et al.
Publicado: (2016)

Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease
por: Wang, Shudan, et al.
Publicado: (2020)

Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
por: Ramsey, Arren, et al.
Publicado: (2023)

Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage
por: Wu, Chun-Hu, et al.
Publicado: (2019)

Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase
por: Chen, Chun, et al.
Publicado: (2021)

A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability
por: Seese, Ronald R., et al.
Publicado: (2019)

The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice
por: Johnstone, Maddison R., et al.
Publicado: (2021)

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
por: Vidaurre, Ó G, et al.
Publicado: (2012)

Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6
por: Cook, Anna A., et al.
Publicado: (2022)

Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy
por: Hennlein, Luisa, et al.
Publicado: (2023)

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates
por: Lin, John C., et al.
Publicado: (2008)

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease
por: Todd, Daniel, et al.
Publicado: (2014)

Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction
por: Greising, Sarah M., et al.
Publicado: (2017)

TrkB-Targeted Therapy for Mucoepidermoid Carcinoma
por: Wagner, Vivian P., et al.
Publicado: (2020)

Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons
por: Tacke, Charlotte, et al.
Publicado: (2022)

Taste Neurons Consist of Both a Large TrkB-Receptor-Dependent and a Small TrkB-Receptor-Independent Subpopulation
por: Fei, Da, et al.
Publicado: (2013)

The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD
por: Green, Christopher R., et al.
Publicado: (2013)

Bidirectional coordination of actions and habits by TrkB in mice
por: Pitts, Elizabeth G., et al.
Publicado: (2018)

Cholinergic neuroplasticity in asthma driven by TrkB signaling
por: Dragunas, Guilherme, et al.
Publicado: (2020)

Legumain Functions as a Transient TrkB Sheddase
por: Holzner, Christoph, et al.
Publicado: (2023)

Linking Hypothermia and Altered Metabolism with TrkB Activation
por: Alitalo, Okko, et al.
Publicado: (2023)

Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling
por: Zorzin, Stefania, et al.
Publicado: (2021)

Trk agonist drugs rescue noise-induced hidden hearing loss
por: Fernandez, Katharine A., et al.
Publicado: (2021)

Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC
por: Ateaque, Sarah, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vdd5co6etohb0nmc5u5561e7ec