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Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men
PURPOSE: The pressure and stress caused by some intense exercises cause changes in histone proteins and gene expression. The aim of this study was to investigate the effect of one session of intensive exercise with supplementation of ginseng, on the methylation of H3K‐36 histone protein in skeletal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503167/ https://www.ncbi.nlm.nih.gov/pubmed/30920174 http://dx.doi.org/10.1002/mgg3.651 |
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author | Naghavi moghadam, Ali akbar Shiravand, Mostafa Rezapour, Sadegh Khoshdel, Alireza Bazgir, Behzad Mardani, Mahnaz |
author_facet | Naghavi moghadam, Ali akbar Shiravand, Mostafa Rezapour, Sadegh Khoshdel, Alireza Bazgir, Behzad Mardani, Mahnaz |
author_sort | Naghavi moghadam, Ali akbar |
collection | PubMed |
description | PURPOSE: The pressure and stress caused by some intense exercises cause changes in histone proteins and gene expression. The aim of this study was to investigate the effect of one session of intensive exercise with supplementation of ginseng, on the methylation of H3K‐36 histone protein in skeletal muscle of young nonathlete men. METHODS: After the approval by the ethics committee, 12 untrained male subjects were randomly assigned to either exercise group (six subjects) or exercise and supplement group. First, from both groups, the muscular sample was taken from the broad‐lateral muscle of the subjects. Immediately after the muscle biopsy, exercise and exercise + supplement groups completed the exercise protocol. During this period, the exercise + supplement group consumed ginseng supplementation and took placebo group. Immediately after exercise, all subjects were retested. RESULTS: There was no significant increase in histone H3‐k36 protein methylation in the intergroup between exercise + supplementation and exercise. There was a significant difference within the training group but there was no difference in the exercise + supplementation group. CONCLUSION: The methylation caused by intense physical pressure, can be reduced by ginseng extract. |
format | Online Article Text |
id | pubmed-6503167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65031672019-05-10 Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men Naghavi moghadam, Ali akbar Shiravand, Mostafa Rezapour, Sadegh Khoshdel, Alireza Bazgir, Behzad Mardani, Mahnaz Mol Genet Genomic Med Original Articles PURPOSE: The pressure and stress caused by some intense exercises cause changes in histone proteins and gene expression. The aim of this study was to investigate the effect of one session of intensive exercise with supplementation of ginseng, on the methylation of H3K‐36 histone protein in skeletal muscle of young nonathlete men. METHODS: After the approval by the ethics committee, 12 untrained male subjects were randomly assigned to either exercise group (six subjects) or exercise and supplement group. First, from both groups, the muscular sample was taken from the broad‐lateral muscle of the subjects. Immediately after the muscle biopsy, exercise and exercise + supplement groups completed the exercise protocol. During this period, the exercise + supplement group consumed ginseng supplementation and took placebo group. Immediately after exercise, all subjects were retested. RESULTS: There was no significant increase in histone H3‐k36 protein methylation in the intergroup between exercise + supplementation and exercise. There was a significant difference within the training group but there was no difference in the exercise + supplementation group. CONCLUSION: The methylation caused by intense physical pressure, can be reduced by ginseng extract. John Wiley and Sons Inc. 2019-03-28 /pmc/articles/PMC6503167/ /pubmed/30920174 http://dx.doi.org/10.1002/mgg3.651 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Naghavi moghadam, Ali akbar Shiravand, Mostafa Rezapour, Sadegh Khoshdel, Alireza Bazgir, Behzad Mardani, Mahnaz Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men |
title | Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men |
title_full | Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men |
title_fullStr | Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men |
title_full_unstemmed | Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men |
title_short | Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men |
title_sort | effect of a session of intensive exercise with ginseng supplementation on histone h3 protein methylation of skeletal muscle of nonathlete men |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503167/ https://www.ncbi.nlm.nih.gov/pubmed/30920174 http://dx.doi.org/10.1002/mgg3.651 |
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