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Arterial stiffness during whole‐body passive heat stress in healthy older adults

We tested the hypothesis that whole‐body passive heat stress reduces arterial stiffness in older adults. At preheat stress (baseline) and when core temperature was elevated by 0.6 ± 0.2°C (mild) and 1.2 ± 0.3°C (moderate), arterial stiffness was measured in eight healthy younger (26 ± 5 years) and e...

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Autores principales: Schlader, Zachary J., Okada, Yoshiyuki, Best, Stuart A., Fu, Qi, Crandall, Craig G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503298/
https://www.ncbi.nlm.nih.gov/pubmed/31062476
http://dx.doi.org/10.14814/phy2.14094
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author Schlader, Zachary J.
Okada, Yoshiyuki
Best, Stuart A.
Fu, Qi
Crandall, Craig G.
author_facet Schlader, Zachary J.
Okada, Yoshiyuki
Best, Stuart A.
Fu, Qi
Crandall, Craig G.
author_sort Schlader, Zachary J.
collection PubMed
description We tested the hypothesis that whole‐body passive heat stress reduces arterial stiffness in older adults. At preheat stress (baseline) and when core temperature was elevated by 0.6 ± 0.2°C (mild) and 1.2 ± 0.3°C (moderate), arterial stiffness was measured in eight healthy younger (26 ± 5 years) and eight healthy older (70 ± 4 years) adults in the supine position. Arterial stiffness was estimated from carotid‐to‐femoral pulse wave velocity (cfPWV, applanation tonometry). cfPWV was higher at baseline in older adults (8.8 ± 2.3 m/sec vs. 5.6 ± 0.9 m/sec, P < 0.01) and this difference was maintained throughout passive heat stress (P < 0.01). cfPWV did not change (P ≥ 0.49) with passive heat stress in either younger (at moderate heat stress: 6.0 ± 1.0 m/sec) or older (at moderate heat stress: 8.5 ± 1.6 m/sec) adults. However, the influence of baseline cfPWV on the change in cfPWV during mild (r = −0.66, P = 0.04) and moderate (r = −0.87, P < 0.01) heat stress were inversely related in older adults, and the strength of these relations was not statistically different (P = 0.08). In younger adults, the influence of baseline cfPWV on the change in cfPWV during mild heat stress was also inversely related (r = −0.79, P = 0.01), while the strength of this relation was attenuated at moderate heat stress (r = −0.24, P = 0.30). Changes in arterial stiffness during passive heat stress in adults aged ≥65 year are likely dependent on the magnitude of baseline arterial stiffness and not necessarily age.
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spelling pubmed-65032982019-05-10 Arterial stiffness during whole‐body passive heat stress in healthy older adults Schlader, Zachary J. Okada, Yoshiyuki Best, Stuart A. Fu, Qi Crandall, Craig G. Physiol Rep Original Research We tested the hypothesis that whole‐body passive heat stress reduces arterial stiffness in older adults. At preheat stress (baseline) and when core temperature was elevated by 0.6 ± 0.2°C (mild) and 1.2 ± 0.3°C (moderate), arterial stiffness was measured in eight healthy younger (26 ± 5 years) and eight healthy older (70 ± 4 years) adults in the supine position. Arterial stiffness was estimated from carotid‐to‐femoral pulse wave velocity (cfPWV, applanation tonometry). cfPWV was higher at baseline in older adults (8.8 ± 2.3 m/sec vs. 5.6 ± 0.9 m/sec, P < 0.01) and this difference was maintained throughout passive heat stress (P < 0.01). cfPWV did not change (P ≥ 0.49) with passive heat stress in either younger (at moderate heat stress: 6.0 ± 1.0 m/sec) or older (at moderate heat stress: 8.5 ± 1.6 m/sec) adults. However, the influence of baseline cfPWV on the change in cfPWV during mild (r = −0.66, P = 0.04) and moderate (r = −0.87, P < 0.01) heat stress were inversely related in older adults, and the strength of these relations was not statistically different (P = 0.08). In younger adults, the influence of baseline cfPWV on the change in cfPWV during mild heat stress was also inversely related (r = −0.79, P = 0.01), while the strength of this relation was attenuated at moderate heat stress (r = −0.24, P = 0.30). Changes in arterial stiffness during passive heat stress in adults aged ≥65 year are likely dependent on the magnitude of baseline arterial stiffness and not necessarily age. John Wiley and Sons Inc. 2019-05-07 /pmc/articles/PMC6503298/ /pubmed/31062476 http://dx.doi.org/10.14814/phy2.14094 Text en © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Schlader, Zachary J.
Okada, Yoshiyuki
Best, Stuart A.
Fu, Qi
Crandall, Craig G.
Arterial stiffness during whole‐body passive heat stress in healthy older adults
title Arterial stiffness during whole‐body passive heat stress in healthy older adults
title_full Arterial stiffness during whole‐body passive heat stress in healthy older adults
title_fullStr Arterial stiffness during whole‐body passive heat stress in healthy older adults
title_full_unstemmed Arterial stiffness during whole‐body passive heat stress in healthy older adults
title_short Arterial stiffness during whole‐body passive heat stress in healthy older adults
title_sort arterial stiffness during whole‐body passive heat stress in healthy older adults
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503298/
https://www.ncbi.nlm.nih.gov/pubmed/31062476
http://dx.doi.org/10.14814/phy2.14094
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