Cargando…
Issues and opportunities of stem cell therapy in autoimmune diseases
The purpose of regenerative medicine is to restore or enhance the normal function of human cells, tissues, and organs. From a clinical point of view, the use of stem cells is more advantageous than differentiated cells because they can be collected more easily and in larger quantities, their prolife...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503459/ https://www.ncbi.nlm.nih.gov/pubmed/31110602 http://dx.doi.org/10.4252/wjsc.v11.i4.212 |
_version_ | 1783416416837304320 |
---|---|
author | Műzes, Györgyi Sipos, Ferenc |
author_facet | Műzes, Györgyi Sipos, Ferenc |
author_sort | Műzes, Györgyi |
collection | PubMed |
description | The purpose of regenerative medicine is to restore or enhance the normal function of human cells, tissues, and organs. From a clinical point of view, the use of stem cells is more advantageous than differentiated cells because they can be collected more easily and in larger quantities, their proliferation capacity is more pronounced, they are more resistant in cell culture, their aging is delayed, they are able to form a number of cell lines, and they are able to promote vascularization of tissue carriers. The therapeutic use of stem cells for disease modification, immunomodulation, or regenerative purposes are undoubtedly encouraging, but most studies are still in their early stages, and the clinical results reported are not clear with regard to therapeutic efficacy and potential side effects. Uniform regulation of the clinical application of stem cells is also indispensable for this highly customizable, minimally invasive, individualized therapeutic method to become a successful and safe treatment alternative in many different autoimmune and autoinflammatory disorders. |
format | Online Article Text |
id | pubmed-6503459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-65034592019-05-20 Issues and opportunities of stem cell therapy in autoimmune diseases Műzes, Györgyi Sipos, Ferenc World J Stem Cells Review The purpose of regenerative medicine is to restore or enhance the normal function of human cells, tissues, and organs. From a clinical point of view, the use of stem cells is more advantageous than differentiated cells because they can be collected more easily and in larger quantities, their proliferation capacity is more pronounced, they are more resistant in cell culture, their aging is delayed, they are able to form a number of cell lines, and they are able to promote vascularization of tissue carriers. The therapeutic use of stem cells for disease modification, immunomodulation, or regenerative purposes are undoubtedly encouraging, but most studies are still in their early stages, and the clinical results reported are not clear with regard to therapeutic efficacy and potential side effects. Uniform regulation of the clinical application of stem cells is also indispensable for this highly customizable, minimally invasive, individualized therapeutic method to become a successful and safe treatment alternative in many different autoimmune and autoinflammatory disorders. Baishideng Publishing Group Inc 2019-04-26 2019-04-26 /pmc/articles/PMC6503459/ /pubmed/31110602 http://dx.doi.org/10.4252/wjsc.v11.i4.212 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Műzes, Györgyi Sipos, Ferenc Issues and opportunities of stem cell therapy in autoimmune diseases |
title | Issues and opportunities of stem cell therapy in autoimmune diseases |
title_full | Issues and opportunities of stem cell therapy in autoimmune diseases |
title_fullStr | Issues and opportunities of stem cell therapy in autoimmune diseases |
title_full_unstemmed | Issues and opportunities of stem cell therapy in autoimmune diseases |
title_short | Issues and opportunities of stem cell therapy in autoimmune diseases |
title_sort | issues and opportunities of stem cell therapy in autoimmune diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503459/ https://www.ncbi.nlm.nih.gov/pubmed/31110602 http://dx.doi.org/10.4252/wjsc.v11.i4.212 |
work_keys_str_mv | AT muzesgyorgyi issuesandopportunitiesofstemcelltherapyinautoimmunediseases AT siposferenc issuesandopportunitiesofstemcelltherapyinautoimmunediseases |