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Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

[Image: see text] Catechol-O-methyltransferase (COMT) is a model S-adenosyl-l-methionine (SAM) dependent methyl transferase, which catalyzes the methylation of catecholamine neurotransmitters such as dopamine in the primary pathway of neurotransmitter deactivation in animals. Despite extensive study...

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Detalles Bibliográficos
Autores principales:	Czarnota, Sylwia, Johannissen, Linus O., Baxter, Nicola J., Rummel, Felix, Wilson, Alex L., Cliff, Matthew J., Levy, Colin W., Scrutton, Nigel S., Waltho, Jonathan P., Hay, Sam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503465/ https://www.ncbi.nlm.nih.gov/pubmed/31080692 http://dx.doi.org/10.1021/acscatal.9b00174

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