Cargando…

Use of PBPK Modeling To Evaluate the Performance of DissolvIt, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products

[Image: see text] The dissolution of inhaled drug particles in the lungs is a challenge to model using biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and dose, (ii) presenting this to a small volume of medium that is representative of lung lining fluid, and (iii...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hassoun, Mireille, Malmlöf, Maria, Scheibelhofer, Otto, Kumar, Abhinav, Bansal, Sukhi, Selg, Ewa, Nowenwik, Mattias, Gerde, Per, Radivojev, Snezana, Paudel, Amrit, Arora, Sumit, Forbes, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503535/ https://www.ncbi.nlm.nih.gov/pubmed/30640475 http://dx.doi.org/10.1021/acs.molpharmaceut.8b01200

Ejemplares similares

Adapting the Aerogen Mesh Nebulizer for Dried Aerosol Exposures Using the PreciseInhale Platform
por: Gerde, Per, et al.
Publicado: (2020)

Design and development of a biorelevant simulated human lung fluid
por: Hassoun, Mireille, et al.
Publicado: (2018)

Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution
por: Eason, Thomas, et al.
Publicado: (2022)

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
por: Teleki, Alexandra, et al.
Publicado: (2020)

Development and Validation of Discriminating and Biorelevant Dissolution Test for Lornoxicam Tablets
por: Anumolu, P. D., et al.
Publicado: (2015)

Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis
por: Stupák, Ivan, et al.
Publicado: (2017)

Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system
por: Yadav, Ankit Kumar, et al.
Publicado: (2017)

Dissolution of Pentoxifylline from Extended Release Formulations. Researches Concerning Development of a Biorelevant Test
por: Ionica, Georgeta, et al.
Publicado: (2009)

Dissolution Profile of Mefenamic Acid Solid Dosage Forms in Two Compendial and Biorelevant (FaSSIF) Media
por: Nurhikmah, Wilda, et al.
Publicado: (2016)

The Effect of Biorelevant Hydrodynamic Conditions on Drug Dissolution from Extended-Release Tablets in the Dynamic Colon Model
por: O’Farrell, Connor, et al.
Publicado: (2022)

Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
por: Denninger, Alexander, et al.
Publicado: (2023)

The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character
por: Csicsák, Dóra, et al.
Publicado: (2023)

Biorelevant test for supersaturable formulation
por: Lu, Enxian, et al.
Publicado: (2017)

Exploration of Neusilin(®) US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study
por: Bílik, Tomáš, et al.
Publicado: (2022)

Role of Biorelevant Dissolution Media in the Selection of Optimal Salt Forms of Oral Drugs: Maximizing the Gastrointestinal Solubility and in Vitro Activity of the Antimicrobial Molecule, Clofazimine
por: Bannigan, Pauric, et al.
Publicado: (2017)

A Rational Design of a Biphasic Dissolution Setup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion
por: Denninger, Alexander, et al.
Publicado: (2020)

Development of Combining of Human Bronchial Mucosa Models with XposeALI® for Exposure of Air Pollution Nanoparticles
por: Ji, Jie, et al.
Publicado: (2017)

Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization
por: Ji, Jie, et al.
Publicado: (2018)

Image-Based Investigation: Biorelevant Solubility of α and γ Indomethacin
por: Štukelj, Jernej, et al.
Publicado: (2019)

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
por: Kuepfer, L, et al.
Publicado: (2016)

The Effect of Crospovidone on the Dissolution Profile of Amlodipine Besylate from Fast Orally Dissolving Film
por: Sumaiyah, Sumaiyah, et al.
Publicado: (2019)

Effect of Enzymatic Depolymerization of Cellulose and Hemicelluloses on the Direct Dissolution of Prehydrolysis Kraft Dissolving Pulp
por: Ceccherini, Sara, et al.
Publicado: (2021)

Near-Infrared Hyperspectral Imaging as a Monitoring Tool for On-Demand Manufacturing of Inkjet-Printed Formulations
por: Stranzinger, Sandra, et al.
Publicado: (2021)

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling
por: Han, Chunyan, et al.
Publicado: (2023)

Antifungal Activities of Biorelevant Complexes of Copper(II) with Biosensitive Macrocyclic Ligands
por: Raman, N., et al.
Publicado: (2006)

MPTHub: An Open-Source Software for Characterizing the Transport of Particles in Biorelevant Media
por: Gabriel, Leandro, et al.
Publicado: (2022)

Development of Test Programs for the Biorelevant Characterization of Esophageal-Applied Dosage Forms
por: Brokmann, Friederike, et al.
Publicado: (2023)

Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model
por: Shuklinova, Olha, et al.
Publicado: (2022)

Experimental and Simulation Study on the Dissolved Amount and Dissolution Rate of Supercritical CO(2) in Polystyrene Melt
por: Wang, Duyang, et al.
Publicado: (2019)

Silver nanoparticles: aggregation behavior in biorelevant conditions and its impact on biological activity
por: Bélteky, Péter, et al.
Publicado: (2019)

IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical Stress
por: Mohylyuk, Valentyn, et al.
Publicado: (2020)

Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and Erythritol
por: Maeng, Han-Joo, et al.
Publicado: (2019)

Magnetic Resonance Methods as a Prognostic Tool for the Biorelevant Behavior of Xanthan Tablets
por: Mikac, Urša, et al.
Publicado: (2020)

Ultrasensitive Optical Fingerprinting of Biorelevant Molecules by Means of SERS-Mapping on Nanostructured Metasurfaces
por: Kozhina, Elizaveta, et al.
Publicado: (2022)

Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering
por: Loussouarn, Aurélie, et al.
Publicado: (2020)

Peptide Side-COOH Groups Have Two Distinct Conformations under Biorelevant Conditions
por: Sofronov, Oleksandr O., et al.
Publicado: (2020)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK
por: Wagner, C, et al.
Publicado: (2015)

Key Intermediate Species Reveal the Copper(II)‐Exchange Pathway in Biorelevant ATCUN/NTS Complexes
por: Kotuniak, Radosław, et al.
Publicado: (2020)

AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite
por: Fási, Laura, et al.
Publicado: (2020)

Biorelevant In Vitro Release Testing and In Vivo Study of Extended-Release Niacin Hydrophilic Matrix Tablets
por: Milanowski, Bartłomiej, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ulup23rt1bolmg83d9b8p4ofh9