Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes

[Image: see text] Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols....

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Autores principales: Daw, Prosenjit, Kumar, Amit, Espinosa-Jalapa, Noel Angel, Diskin-Posner, Yael, Ben-David, Yehoshoa, Milstein, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503583/
https://www.ncbi.nlm.nih.gov/pubmed/31080687
http://dx.doi.org/10.1021/acscatal.8b02208
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author Daw, Prosenjit
Kumar, Amit
Espinosa-Jalapa, Noel Angel
Diskin-Posner, Yael
Ben-David, Yehoshoa
Milstein, David
author_facet Daw, Prosenjit
Kumar, Amit
Espinosa-Jalapa, Noel Angel
Diskin-Posner, Yael
Ben-David, Yehoshoa
Milstein, David
author_sort Daw, Prosenjit
collection PubMed
description [Image: see text] Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.
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spelling pubmed-65035832019-05-08 Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes Daw, Prosenjit Kumar, Amit Espinosa-Jalapa, Noel Angel Diskin-Posner, Yael Ben-David, Yehoshoa Milstein, David ACS Catal [Image: see text] Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese. American Chemical Society 2018-07-23 2018-09-07 /pmc/articles/PMC6503583/ /pubmed/31080687 http://dx.doi.org/10.1021/acscatal.8b02208 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Daw, Prosenjit
Kumar, Amit
Espinosa-Jalapa, Noel Angel
Diskin-Posner, Yael
Ben-David, Yehoshoa
Milstein, David
Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
title Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
title_full Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
title_fullStr Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
title_full_unstemmed Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
title_short Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
title_sort synthesis of pyrazines and quinoxalines via acceptorless dehydrogenative coupling routes catalyzed by manganese pincer complexes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503583/
https://www.ncbi.nlm.nih.gov/pubmed/31080687
http://dx.doi.org/10.1021/acscatal.8b02208
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