Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine

New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified ele...

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Detalles Bibliográficos
Autores principales: Tariq, Zeshan, Board, Nathan, Eftimiades, Alex, Ibrahim, Ronnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503587/
https://www.ncbi.nlm.nih.gov/pubmed/31105954
http://dx.doi.org/10.1177/2050313X19847804
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author Tariq, Zeshan
Board, Nathan
Eftimiades, Alex
Ibrahim, Ronnie
author_facet Tariq, Zeshan
Board, Nathan
Eftimiades, Alex
Ibrahim, Ronnie
author_sort Tariq, Zeshan
collection PubMed
description New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine. This drug binds to the 5-HT(2A) receptor inhibiting tumor necrosis factor alpha signaling. Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.
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spelling pubmed-65035872019-05-17 Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine Tariq, Zeshan Board, Nathan Eftimiades, Alex Ibrahim, Ronnie SAGE Open Med Case Rep Case Report New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine. This drug binds to the 5-HT(2A) receptor inhibiting tumor necrosis factor alpha signaling. Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology. SAGE Publications 2019-05-06 /pmc/articles/PMC6503587/ /pubmed/31105954 http://dx.doi.org/10.1177/2050313X19847804 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Tariq, Zeshan
Board, Nathan
Eftimiades, Alex
Ibrahim, Ronnie
Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
title Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
title_full Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
title_fullStr Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
title_full_unstemmed Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
title_short Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
title_sort resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, venlafaxine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503587/
https://www.ncbi.nlm.nih.gov/pubmed/31105954
http://dx.doi.org/10.1177/2050313X19847804
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