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Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction

BACKGROUND: Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) contributes to increased systemic inflammation, oxidative stress, hypoxia, hypercapnia and other risk factors of the skeletal muscle dysfunction. AIMS AND OBJECTIVES: This study aimed to determine whether the frequency of the C...

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Autores principales: Poberezhets, Vitalii, Mostovoy, Yuriy, Demchuk, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503710/
https://www.ncbi.nlm.nih.gov/pubmed/31031336
http://dx.doi.org/10.4103/lungindia.lungindia_185_18
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author Poberezhets, Vitalii
Mostovoy, Yuriy
Demchuk, Hanna
author_facet Poberezhets, Vitalii
Mostovoy, Yuriy
Demchuk, Hanna
author_sort Poberezhets, Vitalii
collection PubMed
description BACKGROUND: Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) contributes to increased systemic inflammation, oxidative stress, hypoxia, hypercapnia and other risk factors of the skeletal muscle dysfunction. AIMS AND OBJECTIVES: This study aimed to determine whether the frequency of the COPD exacerbations promotes deterioration of the skeletal muscle dysfunction in patients with COPD and to figure out which characteristics of the muscles will reflect this changes. MATERIALS AND METHODS: We examined 98 male COPD patients, mean age 60.4±11.2 years, GOLD groups B, C, D. To assess the degree of skeletal muscle dysfunction we used hand-grip strength, 6-minute walk test, bioelectrical impedance analysis. Quality of life was evaluated using St. George's respiratory questionnaire (SGRQ). RESULTS: Increase in the frequency of COPD exacerbations was associated with the decrease in the 6-minute walk test distance (r= -0.214, P = 0.034) and with the rise of sarcopenia according to the results of bioelectrical impedance analysis – lower fat-free mass index (r = -0.201, P = 0.047). Frequency of COPD exacerbations had a weak correlation with the degree of the activity limitation component of SGRQ (r = 0.436, P < 0.001). CONCLUSIONS: COPD exacerbation plays an important role in progression of the skeletal muscle dysfunction. It decreases endurance of the skeletal muscles, diminishing their size, which manifests itself in reduced exercise tolerance. Increase in the frequency of the COPD exacerbations also worsens all components of the life quality.
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spelling pubmed-65037102019-05-10 Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction Poberezhets, Vitalii Mostovoy, Yuriy Demchuk, Hanna Lung India Original Article BACKGROUND: Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) contributes to increased systemic inflammation, oxidative stress, hypoxia, hypercapnia and other risk factors of the skeletal muscle dysfunction. AIMS AND OBJECTIVES: This study aimed to determine whether the frequency of the COPD exacerbations promotes deterioration of the skeletal muscle dysfunction in patients with COPD and to figure out which characteristics of the muscles will reflect this changes. MATERIALS AND METHODS: We examined 98 male COPD patients, mean age 60.4±11.2 years, GOLD groups B, C, D. To assess the degree of skeletal muscle dysfunction we used hand-grip strength, 6-minute walk test, bioelectrical impedance analysis. Quality of life was evaluated using St. George's respiratory questionnaire (SGRQ). RESULTS: Increase in the frequency of COPD exacerbations was associated with the decrease in the 6-minute walk test distance (r= -0.214, P = 0.034) and with the rise of sarcopenia according to the results of bioelectrical impedance analysis – lower fat-free mass index (r = -0.201, P = 0.047). Frequency of COPD exacerbations had a weak correlation with the degree of the activity limitation component of SGRQ (r = 0.436, P < 0.001). CONCLUSIONS: COPD exacerbation plays an important role in progression of the skeletal muscle dysfunction. It decreases endurance of the skeletal muscles, diminishing their size, which manifests itself in reduced exercise tolerance. Increase in the frequency of the COPD exacerbations also worsens all components of the life quality. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6503710/ /pubmed/31031336 http://dx.doi.org/10.4103/lungindia.lungindia_185_18 Text en Copyright: © 2019 Indian Chest Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Poberezhets, Vitalii
Mostovoy, Yuriy
Demchuk, Hanna
Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
title Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
title_full Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
title_fullStr Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
title_full_unstemmed Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
title_short Exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
title_sort exacerbation of chronic obstructive pulmonary diseases as a risk factor of the skeletal muscle dysfunction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503710/
https://www.ncbi.nlm.nih.gov/pubmed/31031336
http://dx.doi.org/10.4103/lungindia.lungindia_185_18
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