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Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
BACKGROUND: The extent of involvement of cervical lymph nodes is known to be the most important prognosticator in oral squamous cell carcinoma (SCC) that significantly affects the survival rate of patients. The clinical, radiological and pathological factors that can predict cervical lymph node meta...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503798/ https://www.ncbi.nlm.nih.gov/pubmed/31110414 http://dx.doi.org/10.4103/jomfp.JOMFP_132_17 |
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author | Nayanar, Sangeetha Keloth Tripathy, Jaya Prasad Duraisamy, Karthickeyan Babu, Sajith |
author_facet | Nayanar, Sangeetha Keloth Tripathy, Jaya Prasad Duraisamy, Karthickeyan Babu, Sajith |
author_sort | Nayanar, Sangeetha Keloth |
collection | PubMed |
description | BACKGROUND: The extent of involvement of cervical lymph nodes is known to be the most important prognosticator in oral squamous cell carcinoma (SCC) that significantly affects the survival rate of patients. The clinical, radiological and pathological factors that can predict cervical lymph node metastasis are yet to be ascertained clearly, which poses a challenge for the surgeon to determine the extent of neck dissection. AIM: This study aims to identify the clinical and histopathologic predictors of lymph node metastasis among patients with oral SCC and to devise a scoring system based on those predictors to aid in better clinical decision-making regarding the extent of neck dissection. SETTING: Malabar Cancer Centre, a specialized tertiary cancer care center in Kerala, India. METHODS: A retrospective review of 160 patient records and biopsy slides collected and preserved between June 2014 and May 2016. CONCLUSION: The clinicopathologic parameters such as site of cancer (P = 0.03), histologic differentiation (P = 0.03), shape of rete pegs (P = 0.002), pattern of invasion (P = 0.0001) and depth of invasion >3 mm (P = 0.016) were significantly associated with the risk of lymph node metastasis. The risk score devised based on these predictors serves as an efficient tool in aiding clinical decision-making regarding the extent of neck dissection. |
format | Online Article Text |
id | pubmed-6503798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-65037982019-05-20 Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma Nayanar, Sangeetha Keloth Tripathy, Jaya Prasad Duraisamy, Karthickeyan Babu, Sajith J Oral Maxillofac Pathol Original Article BACKGROUND: The extent of involvement of cervical lymph nodes is known to be the most important prognosticator in oral squamous cell carcinoma (SCC) that significantly affects the survival rate of patients. The clinical, radiological and pathological factors that can predict cervical lymph node metastasis are yet to be ascertained clearly, which poses a challenge for the surgeon to determine the extent of neck dissection. AIM: This study aims to identify the clinical and histopathologic predictors of lymph node metastasis among patients with oral SCC and to devise a scoring system based on those predictors to aid in better clinical decision-making regarding the extent of neck dissection. SETTING: Malabar Cancer Centre, a specialized tertiary cancer care center in Kerala, India. METHODS: A retrospective review of 160 patient records and biopsy slides collected and preserved between June 2014 and May 2016. CONCLUSION: The clinicopathologic parameters such as site of cancer (P = 0.03), histologic differentiation (P = 0.03), shape of rete pegs (P = 0.002), pattern of invasion (P = 0.0001) and depth of invasion >3 mm (P = 0.016) were significantly associated with the risk of lymph node metastasis. The risk score devised based on these predictors serves as an efficient tool in aiding clinical decision-making regarding the extent of neck dissection. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6503798/ /pubmed/31110414 http://dx.doi.org/10.4103/jomfp.JOMFP_132_17 Text en Copyright: © 2019 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Nayanar, Sangeetha Keloth Tripathy, Jaya Prasad Duraisamy, Karthickeyan Babu, Sajith Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
title | Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
title_full | Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
title_fullStr | Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
title_full_unstemmed | Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
title_short | Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
title_sort | prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503798/ https://www.ncbi.nlm.nih.gov/pubmed/31110414 http://dx.doi.org/10.4103/jomfp.JOMFP_132_17 |
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