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Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma

BACKGROUND: The extent of involvement of cervical lymph nodes is known to be the most important prognosticator in oral squamous cell carcinoma (SCC) that significantly affects the survival rate of patients. The clinical, radiological and pathological factors that can predict cervical lymph node meta...

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Autores principales: Nayanar, Sangeetha Keloth, Tripathy, Jaya Prasad, Duraisamy, Karthickeyan, Babu, Sajith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503798/
https://www.ncbi.nlm.nih.gov/pubmed/31110414
http://dx.doi.org/10.4103/jomfp.JOMFP_132_17
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author Nayanar, Sangeetha Keloth
Tripathy, Jaya Prasad
Duraisamy, Karthickeyan
Babu, Sajith
author_facet Nayanar, Sangeetha Keloth
Tripathy, Jaya Prasad
Duraisamy, Karthickeyan
Babu, Sajith
author_sort Nayanar, Sangeetha Keloth
collection PubMed
description BACKGROUND: The extent of involvement of cervical lymph nodes is known to be the most important prognosticator in oral squamous cell carcinoma (SCC) that significantly affects the survival rate of patients. The clinical, radiological and pathological factors that can predict cervical lymph node metastasis are yet to be ascertained clearly, which poses a challenge for the surgeon to determine the extent of neck dissection. AIM: This study aims to identify the clinical and histopathologic predictors of lymph node metastasis among patients with oral SCC and to devise a scoring system based on those predictors to aid in better clinical decision-making regarding the extent of neck dissection. SETTING: Malabar Cancer Centre, a specialized tertiary cancer care center in Kerala, India. METHODS: A retrospective review of 160 patient records and biopsy slides collected and preserved between June 2014 and May 2016. CONCLUSION: The clinicopathologic parameters such as site of cancer (P = 0.03), histologic differentiation (P = 0.03), shape of rete pegs (P = 0.002), pattern of invasion (P = 0.0001) and depth of invasion >3 mm (P = 0.016) were significantly associated with the risk of lymph node metastasis. The risk score devised based on these predictors serves as an efficient tool in aiding clinical decision-making regarding the extent of neck dissection.
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spelling pubmed-65037982019-05-20 Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma Nayanar, Sangeetha Keloth Tripathy, Jaya Prasad Duraisamy, Karthickeyan Babu, Sajith J Oral Maxillofac Pathol Original Article BACKGROUND: The extent of involvement of cervical lymph nodes is known to be the most important prognosticator in oral squamous cell carcinoma (SCC) that significantly affects the survival rate of patients. The clinical, radiological and pathological factors that can predict cervical lymph node metastasis are yet to be ascertained clearly, which poses a challenge for the surgeon to determine the extent of neck dissection. AIM: This study aims to identify the clinical and histopathologic predictors of lymph node metastasis among patients with oral SCC and to devise a scoring system based on those predictors to aid in better clinical decision-making regarding the extent of neck dissection. SETTING: Malabar Cancer Centre, a specialized tertiary cancer care center in Kerala, India. METHODS: A retrospective review of 160 patient records and biopsy slides collected and preserved between June 2014 and May 2016. CONCLUSION: The clinicopathologic parameters such as site of cancer (P = 0.03), histologic differentiation (P = 0.03), shape of rete pegs (P = 0.002), pattern of invasion (P = 0.0001) and depth of invasion >3 mm (P = 0.016) were significantly associated with the risk of lymph node metastasis. The risk score devised based on these predictors serves as an efficient tool in aiding clinical decision-making regarding the extent of neck dissection. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6503798/ /pubmed/31110414 http://dx.doi.org/10.4103/jomfp.JOMFP_132_17 Text en Copyright: © 2019 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Nayanar, Sangeetha Keloth
Tripathy, Jaya Prasad
Duraisamy, Karthickeyan
Babu, Sajith
Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
title Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
title_full Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
title_fullStr Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
title_full_unstemmed Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
title_short Prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
title_sort prognostic efficiency of clinicopathologic scoring to predict cervical lymph node metastasis in oral squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503798/
https://www.ncbi.nlm.nih.gov/pubmed/31110414
http://dx.doi.org/10.4103/jomfp.JOMFP_132_17
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