Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

Sphingolipid (SL) metabolism alterations have been frequently reported in cancer including in melanoma, a bad-prognosis skin cancer. In normal cells, de novo synthesized ceramide is mainly converted to sphingomyelin (SM), the most abundant SL, by sphingomyelin synthase 1 (SMS1) and, albeit to a less...

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Detalles Bibliográficos
Autores principales: Bilal, Fatima, Montfort, Anne, Gilhodes, Julia, Garcia, Virginie, Riond, Joëlle, Carpentier, Stéphane, Filleron, Thomas, Colacios, Céline, Levade, Thierry, Daher, Ahmad, Meyer, Nicolas, Andrieu-Abadie, Nathalie, Ségui, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503817/
https://www.ncbi.nlm.nih.gov/pubmed/31114500
http://dx.doi.org/10.3389/fphar.2019.00443

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