Soft substrate maintains proliferative and adipogenic differentiation potential of human mesenchymal stem cells on long-term expansion by delaying senescence

Human mesenchymal stem cells (hMSCs), during in vitro expansion, gradually lose their distinct spindle morphology, self-renewal ability, multi-lineage differentiation potential and enter replicative senescence. This loss of cellular function is a major roadblock for clinical applications which deman...

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Detalles Bibliográficos
Autores principales: Kureel, Sanjay Kumar, Mogha, Pankaj, Khadpekar, Akshada, Kumar, Vardhman, Joshi, Rohit, Das, Siddhartha, Bellare, Jayesh, Majumder, Abhijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503999/
https://www.ncbi.nlm.nih.gov/pubmed/31023646
http://dx.doi.org/10.1242/bio.039453

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