Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians

Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization of HLA effects is extremely challenging. As a result, the contribution of specific HLA alleles and amino-acid residues to the overall risk of SLE and to r...

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Detalles Bibliográficos
Autores principales: Molineros, Julio E., Looger, Loren L., Kim, Kwangwoo, Okada, Yukinori, Terao, Chikashi, Sun, Celi, Zhou, Xu-jie, Raj, Prithvi, Kochi, Yuta, Suzuki, Akari, Akizuki, Shuji, Nakabo, Shuichiro, Bang, So-Young, Lee, Hye-Soon, Kang, Young Mo, Suh, Chang-Hee, Chung, Won Tae, Park, Yong-Beom, Choe, Jung-Yoon, Shim, Seung-Cheol, Lee, Shin-Seok, Zuo, Xiaoxia, Yamamoto, Kazuhiko, Li, Quan-Zhen, Shen, Nan, Porter, Lauren L., Harley, John B., Chua, Kek Heng, Zhang, Hong, Wakeland, Edward K., Tsao, Betty P., Bae, Sang-Cheol, Nath, Swapan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504188/
https://www.ncbi.nlm.nih.gov/pubmed/31022184
http://dx.doi.org/10.1371/journal.pgen.1008092

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