Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma

Glioblastoma is an incurable brain cancer characterized by high genetic and pathological heterogeneity. Here, we mapped active chromatin landscapes with gene expression, whole exomes, copy number profiles, and DNA methylomes across 44 patient-derived glioblastoma stem cells (GSCs), 50 primary tumors...

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Detalles Bibliográficos
Autores principales: Mack, Stephen C., Singh, Irtisha, Wang, Xiuxing, Hirsch, Rachel, Wu, Quilian, Villagomez, Rosie, Bernatchez, Jean A., Zhu, Zhe, Gimple, Ryan C., Kim, Leo J.Y., Morton, Andrew, Lai, Sisi, Qiu, Zhixin, Prager, Briana C., Bertrand, Kelsey C., Mah, Clarence, Zhou, Wenchao, Lee, Christine, Barnett, Gene H., Vogelbaum, Michael A., Sloan, Andrew E., Chavez, Lukas, Bao, Shideng, Scacheri, Peter C., Siqueira-Neto, Jair L., Lin, Charles Y., Rich, Jeremy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504206/
https://www.ncbi.nlm.nih.gov/pubmed/30948495
http://dx.doi.org/10.1084/jem.20190196

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