Cargando…

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence of self-DNA inside cells poses a risk of triggering unchecked immune responses. The mechanisms limiting induction of inflammation by self-DNA are poorly understood. BLM RecQ–like he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gratia, Matthieu, Rodero, Mathieu P., Conrad, Cécile, Bou Samra, Elias, Maurin, Mathieu, Rice, Gillian I., Duffy, Darragh, Revy, Patrick, Petit, Florence, Dale, Russell C., Crow, Yanick J., Amor-Gueret, Mounira, Manel, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504208/ https://www.ncbi.nlm.nih.gov/pubmed/30936263 http://dx.doi.org/10.1084/jem.20181329

Ejemplares similares

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
por: Llibre, Alba, et al.
Publicado: (2018)

CGAS is a micronucleophagy receptor for the clearance of micronuclei
por: Zhao, Mengmeng, et al.
Publicado: (2021)

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview
por: Rodero, Mathieu P., et al.
Publicado: (2016)

cGAS surveillance of micronuclei links genome instability to innate immunity
por: Mackenzie, Karen J., et al.
Publicado: (2017)

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei
por: MacDonald, Kate M., et al.
Publicado: (2023)

The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling
por: Ren, Hua, et al.
Publicado: (2007)

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein
por: Guo, Rong-Bing, et al.
Publicado: (2007)

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase
por: Rouzeau, Sébastien, et al.
Publicado: (2012)

An Enterobacteriaceae bloom in aging animals is restrained by the gut microbiome
por: Choi, Rebecca, et al.
Publicado: (2023)

NBS1-CtIP–mediated DNA end resection suppresses cGAS binding to micronuclei
por: Abdisalaam, Salim, et al.
Publicado: (2022)

Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation
por: Ma, Chunmei, et al.
Publicado: (2020)

Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A
por: Lepelley, Alice, et al.
Publicado: (2021)

Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation
por: Ku, Joanne Wei Kay, et al.
Publicado: (2020)

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
por: Bou Samra, Elias, et al.
Publicado: (2017)

A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD(+)
por: Silveira, Sandra Cunha, et al.
Publicado: (2020)

Correction to: Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection
por: Rodero, Mathieu Paul, et al.
Publicado: (2021)

Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection
por: Rodero, Mathieu Paul, et al.
Publicado: (2021)

Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease
por: Rice, Gillian I., et al.
Publicado: (2016)

Epigenetic dysregulation from chromosomal transit in micronuclei
por: Agustinus, Albert S., et al.
Publicado: (2023)

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
por: Gentili, Matteo, et al.
Publicado: (2019)

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
por: Gentili, Matteo, et al.
Publicado: (2019)

No threshold dose for micronuclei induction?
por: Diehl-Marshall, I, et al.
Publicado: (1981)

Interplay between RNA viruses and cGAS/STING axis in innate immunity
por: Amurri, Lucia, et al.
Publicado: (2023)

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection
por: Fouquin, Alexis, et al.
Publicado: (2017)

Activation of cGAS/STING pathway upon paramyxovirus infection
por: Iampietro, Mathieu, et al.
Publicado: (2021)

p21(Waf1 )expression is regulated by nuclear intermediate filament vimentin in neuroblastoma
por: Mergui, Xénia, et al.
Publicado: (2010)

BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress
por: Lahkim Bennani-Belhaj, Kenza, et al.
Publicado: (2010)

Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms
por: Gemble, Simon, et al.
Publicado: (2020)

CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI
por: Zhang, Cheng-Zhong, et al.
Publicado: (2015)

Emergence of micronuclei as a genomic biomarker
por: Sabharwal, Robin, et al.
Publicado: (2015)

Micronuclei as a Predictor for Oral Carcinogenesis
por: Kiran, Kamini, et al.
Publicado: (2018)

A MATLAB-based program for three-dimensional quantitative analysis of micronuclei reveals that neuroinflammation induces micronuclei formation in the brain
por: Yano, Sarasa, et al.
Publicado: (2021)

Clinical non-penetrance associated with biallelic mutations in the RNase H2 complex
por: Crow, Yanick J
Publicado: (2023)

CHROMOSOME PULVERIZATION IN MICRONUCLEI INDUCED BY TRITIATED THYMIDINE
por: Ikeuchi, Tatsuro, et al.
Publicado: (1972)

Replication of somatic micronuclei in bovine enucleated oocytes
por: Canel, Natalia, et al.
Publicado: (2012)

Chromosomes trapped in micronuclei are liable to segregation errors
por: Soto, Mar, et al.
Publicado: (2018)

Micronuclei and Genome Chaos: Changing the System Inheritance
por: Ye, Christine J., et al.
Publicado: (2019)

Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy
por: Kobayashi, Daijiro, et al.
Publicado: (2020)

The suitability of micronuclei as markers of relative biological effect
por: Heaven, Charlotte J, et al.
Publicado: (2022)

Mitotic clustering of pulverized chromosomes from micronuclei
por: Lin, Yu-Fen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rdcipcl1n7ddi7kb62a4reikt6