When pregnancy tames the wolf

A state of relative immunosuppression exists in normal pregnancy. In this issue of JEM, Hong et al. (https://doi.org/10.1084/jem.20190185) perform blood immunomonitoring in pregnancy, in both healthy women and women with lupus, and observe early and sustained transcriptional modulation of lupus-rela...

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Detalles Bibliográficos
Autores principales: Niewold, Timothy B., Mehta-Lee, Shilpi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504221/
https://www.ncbi.nlm.nih.gov/pubmed/30962247
http://dx.doi.org/10.1084/jem.20190378
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author Niewold, Timothy B.
Mehta-Lee, Shilpi
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Mehta-Lee, Shilpi
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description A state of relative immunosuppression exists in normal pregnancy. In this issue of JEM, Hong et al. (https://doi.org/10.1084/jem.20190185) perform blood immunomonitoring in pregnancy, in both healthy women and women with lupus, and observe early and sustained transcriptional modulation of lupus-related pathways in both groups. When signatures of inflammation did not normalize in lupus, risk of pregnancy complications was increased.
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spelling pubmed-65042212019-11-06 When pregnancy tames the wolf Niewold, Timothy B. Mehta-Lee, Shilpi J Exp Med News A state of relative immunosuppression exists in normal pregnancy. In this issue of JEM, Hong et al. (https://doi.org/10.1084/jem.20190185) perform blood immunomonitoring in pregnancy, in both healthy women and women with lupus, and observe early and sustained transcriptional modulation of lupus-related pathways in both groups. When signatures of inflammation did not normalize in lupus, risk of pregnancy complications was increased. Rockefeller University Press 2019-05-06 2019-04-08 /pmc/articles/PMC6504221/ /pubmed/30962247 http://dx.doi.org/10.1084/jem.20190378 Text en © 2019 Niewold and Mehta-Lee http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Niewold, Timothy B.
Mehta-Lee, Shilpi
When pregnancy tames the wolf
title When pregnancy tames the wolf
title_full When pregnancy tames the wolf
title_fullStr When pregnancy tames the wolf
title_full_unstemmed When pregnancy tames the wolf
title_short When pregnancy tames the wolf
title_sort when pregnancy tames the wolf
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504221/
https://www.ncbi.nlm.nih.gov/pubmed/30962247
http://dx.doi.org/10.1084/jem.20190378
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